Evidence map›Paper›PMID 34831079›Full record

ArticleCells2021

Silencing of the ER and Integrative Stress Responses in the Liver of Mice with Error-Prone Translation.

James Moore, Ivan Osinnii, Amandine Grimm, Björn Oettinghaus, Anne Eckert, Stephan Frank, Erik C Böttger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

James MooreInstitut für Medizinische Mikrobiologie, Universität Zürich, 8006 Zürich, Switzerland.
Ivan OsinniiInstitut für Medizinische Mikrobiologie, Universität Zürich, 8006 Zürich, Switzerland.ORCID 0000-0002-0216-7678
Amandine GrimmTransfaculty Research Platform Molecular and Cognitive Neuroscience, Universität Basel, 4055 Basel, Switzerland.ORCID 0000-0003-3323-1756
Björn OettinghausInstitut für Pathologie, Universitätsspital Basel, 4031 Basel, Switzerland.
Anne EckertTransfaculty Research Platform Molecular and Cognitive Neuroscience, Universität Basel, 4055 Basel, Switzerland.
Stephan FrankInstitut für Pathologie, Universitätsspital Basel, 4031 Basel, Switzerland.ORCID 0000-0001-6165-0187
Erik C BöttgerInstitut für Medizinische Mikrobiologie, Universität Zürich, 8006 Zürich, Switzerland.ORCID 0000-0002-2570-0121
University of Zurich · CHUniversity Hospital of Basel · CHUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Translational errors frequently arise during protein synthesis, producing misfolded and dysfunctional proteins. Chronic stress resulting from translation errors may be particularly relevant in tissues that must synthesize and secrete large amounts of secretory proteins. Here, we studied the proteostasis networks in the liver of mice that express the

Indexed as

Endoplasmic Reticulum StressGene SilencingProtein BiosynthesisAnimalsDisease Models, AnimalDown-RegulationLiverMice, TransgenicMitochondriaProteasome Endopeptidase ComplexProteostasisSirtuin 1Stress GranulesUnfolded Protein ResponseUp-RegulationProteasome Endopeptidase ComplexSirtuin 1error-prone translationER stressER-UPRlivermistranslationproteostasisribosomal misreadingRNA-SeqSirtuin-1

Identifiers

PMID34831079
PMCPMC8616113
OpenAlexW3208485090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.