Evidence map›Paper›PMID 34831038›Full record

ArticleCells2021

Macrophage-Derived Immunoglobulin M Inhibits Inflammatory Responses via Modulating Endoplasmic Reticulum Stress.

Xiaoting Gong, Huige Yan, Junfan Ma, Zhu Zhu, Shenghua Zhang, Weiyan Xu, Jing Huang, Xiaoyan Qiu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiaoting GongDepartment of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Huige YanDepartment of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Junfan MaDepartment of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Zhu ZhuDepartment of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Shenghua ZhangDepartment of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Weiyan XuDepartment of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Jing HuangDepartment of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.ORCID 0000-0002-0814-838X
Xiaoyan QiuDepartment of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

National Natural Science Foundation of China 82030044the China Ministry of Science and Technology 2020YFA0707801
6 · The paper itself

Abstract

Immunoglobulin (Ig), a characteristic marker of B cells, is a multifunctional evolutionary conserved antibody critical for maintaining tissue homeostasis and developing fully protective humoral responses to pathogens. Increasing evidence revealed that Ig is widely expressed in non-immune cells; moreover, Ig produced by different lineages cells plays different biological roles. Recently, it has been reported that monocytes or macrophages also express Ig. However, its function remains unclear. In this study, we further identified that Ig, especially Ig mu heavy chain (IgM), was mainly expressed in mice macrophages. We also analyzed the IgM repertoire characteristic in macrophages and found that the V

Indexed as

Endoplasmic Reticulum StressAgingAnimalsCell MovementEndoplasmic ReticulumEndoplasmic Reticulum Chaperone BiPEndoribonucleasesFocal Adhesion Protein-Tyrosine KinasesImmunoglobulin MInflammationLipopolysaccharidesMacrophage ActivationMacrophagesMiceMice, Inbred BALB CProtein BindingEndoplasmic Reticulum Chaperone BiPEndoribonucleasesErn1 protein, mouseFocal Adhesion Protein-Tyrosine KinasesImmunoglobulin MLipopolysaccharidesProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktRNA, Messengersrc-Family KinasesX-Box Binding Protein 1Xbp1 protein, mouseBipER stressIgMinflammatory responsemacrophage

Identifiers

PMID34831038
PMCPMC8616491
OpenAlexW3205097095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.