Evidence map›Paper›PMID 34831036›Full record

ReviewCells2021

Key Regulators of Autophagosome Closure.

Wenyan Jiang, Xuechai Chen, Cuicui Ji, Wenting Zhang, Jianing Song, Jie Li, Juan Wang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Where and how do mammalian cells shape autophagosomes?The Journal of biological chemistry · 2026
    Review
  4. Article
  5. The role of autophagy in protozoan infections.Frontiers in cellular and infection microbiology · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wenyan JiangCenter of Excellence for Environmental Safety and Biological Effects, Faculty of Environment and Life Sciences, Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Beijing University of Technology, 100 Ping Le Yuan, Chaoyang District, Beijing 100124, China.
Xuechai ChenCenter of Excellence for Environmental Safety and Biological Effects, Faculty of Environment and Life Sciences, Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Beijing University of Technology, 100 Ping Le Yuan, Chaoyang District, Beijing 100124, China.
Cuicui JiCenter of Excellence for Environmental Safety and Biological Effects, Faculty of Environment and Life Sciences, Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Beijing University of Technology, 100 Ping Le Yuan, Chaoyang District, Beijing 100124, China.
Wenting ZhangCenter of Excellence for Environmental Safety and Biological Effects, Faculty of Environment and Life Sciences, Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Beijing University of Technology, 100 Ping Le Yuan, Chaoyang District, Beijing 100124, China.
Jianing SongCenter of Excellence for Environmental Safety and Biological Effects, Faculty of Environment and Life Sciences, Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Beijing University of Technology, 100 Ping Le Yuan, Chaoyang District, Beijing 100124, China.
Jie LiLaboratory for Marine Fisheries and Aquaculture, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
Juan WangCenter of Excellence for Environmental Safety and Biological Effects, Faculty of Environment and Life Sciences, Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Beijing University of Technology, 100 Ping Le Yuan, Chaoyang District, Beijing 100124, China.
Beijing University of Technology · CNMinistry of Agriculture and Rural Affairs · CN

Funding

National Natural Science Foundation of China 91854115, 31970044, 31771571
6 · The paper itself

Abstract

Autophagy is an evolutionarily conserved pathway, in which cytoplasmic components are sequestered within double-membrane vesicles called autophagosomes and then transported into lysosomes or vacuoles for degradation. Over 40 conserved autophagy-related (ATG) genes define the core machinery for the five processes of autophagy: initiation, nucleation, elongation, closure, and fusion. In this review, we focus on one of the least well-characterized events in autophagy, namely the closure of the isolation membrane/phagophore to form the sealed autophagosome. This process is tightly regulated by ESCRT machinery, ATG proteins, Rab GTPase and Rab-related proteins, SNAREs, sphingomyelin, and calcium. We summarize recent progress in the regulation of autophagosome closure and discuss the key questions remaining to be addressed.

Indexed as

AnimalsAutophagosomesCalciumEndosomal Sorting Complexes Required for TransportHumansrab GTP-Binding ProteinsSNARE ProteinsSphingomyelinsCalciumEndosomal Sorting Complexes Required for Transportrab GTP-Binding ProteinsSNARE ProteinsSphingomyelinsautophagosomeautophagyclosureisolation membrane

Identifiers

PMID34831036
PMCPMC8616111
OpenAlexW3206714583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.