Evidence map›Paper›PMID 34831033›Full record

ArticleCells2021

An Inducible System for Silencing Establishment Reveals a Stepwise Mechanism in Which Anchoring at the Nuclear Periphery Precedes Heterochromatin Formation.

Isabelle Loïodice, Mickael Garnier, Ivaylo Nikolov, Angela Taddei

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. A Translocation within thebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Remodeling of perturbed chromatin can initiate de novo transcriptional and post-transcriptional silencing.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Isabelle LoïodiceNuclear Dynamics Unit, CNRS, Institut Curie, PSL University, Sorbonne Université, 75005 Paris, France.
Mickael GarnierNuclear Dynamics Unit, CNRS, Institut Curie, PSL University, Sorbonne Université, 75005 Paris, France.
Ivaylo NikolovNuclear Dynamics Unit, CNRS, Institut Curie, PSL University, Sorbonne Université, 75005 Paris, France.
Angela TaddeiNuclear Dynamics Unit, CNRS, Institut Curie, PSL University, Sorbonne Université, 75005 Paris, France.
Centre National de la Recherche Scientifique · FRDynamique du noyau · FRInstitut Curie · FR

Funding

Agence Nationale de la Recherche ANR-10-IDEX-0001-02 PSLAgence Nationale de la Recherche ANR-10-INBS-04Agence Nationale de la Recherche ANR-11-LABEX-0044 DEEPAgence Nationale de la Recherche ANR-15-CE12-0007
6 · The paper itself

Abstract

In eukaryotic cells, silent chromatin is mainly found at the nuclear periphery forming subnuclear compartments that favor silencing establishment. Here, we set up an inducible system to monitor silencing establishment at an ectopic locus in relation with its subnuclear localization in budding yeast. We previously showed that introducing LacI bound

Indexed as

Gene SilencingCell CycleGenetic LociHeterochromatinNucleosomesProtein BindingProtein StabilitySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsHeterochromatinNucleosomesSaccharomyces cerevisiae ProteinschromatinFROSgene regulationgene silencingheterochromatinnuclear organization

Identifiers

PMID34831033
PMCPMC8616196
OpenAlexW3210838079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.