ArticleCancers2021
Metastatic Lymph Node Ratio for Predicting Recurrence in Medullary Thyroid Cancer.
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The prognostic value of lymph node ratio for thyroid cancer: a meta-analysis.Frontiers in oncology · 2024Pooled it
- Prognostic factors in thyroid cancer with lung-only metastasis: SEER-based retrospective study.Gland surgery · 2026Article
- MYELOstudy: lymph node stage of aggressiveness in medullary thyroid cancer-a retrospective multi-center study analysis.Updates in surgery · 2026Article
- Predicting Structural Progression-Free Survival After Surgery for Medullary Thyroid Carcinoma.World journal of surgery · 2026Observational
- Validation of Lymph Node Thresholds as Prognostic Factors in Medullary Thyroid Cancer Staging.Annals of surgical oncology · 2026Article
- Lymph node ratio and overall survival in patients with colon cancer: a prospective multicentre cohort study.Scientific reports · 2026Article
- Individualized survival prediction in medullary thyroid carcinoma using a least absolute shrinkage and selection operator-Cox-based nomogram.The Journal of international medical research · 2026Article
- Article
- Prognostic factors for progression free survival in patients with medullary thyroid cancer: a multicenter cohort study.Updates in surgery · 2025Article
- Gender, FT4 levels, T stage, and BMI as predictors of TSH levels in thyroid cancer patients.Frontiers in endocrinology · 2025Article
- Time Kinetics and prognosis roles of calcitonin after surgery for medullary thyroid carcinoma.World journal of surgical oncology · 2024Article
- Changes of biochemical factors and the effect on recurrence of medullary thyroid carcinoma after surgery.Heliyon · 2024Article
- Machine learning to predict distant metastasis and prognostic analysis of moderately differentiated gastric adenocarcinoma patients: a novel focus on lymph node indicators.Frontiers in immunology · 2024Article
- A proposed grading scheme for predicting recurrence in medullary thyroid cancer based on the Ki67 index and metastatic lymph node ratio.Endocrine · 2023Article
- Competing-risks model for predicting the prognostic value of lymph nodes in medullary thyroid carcinoma.PloS one · 2023Article
- Value of lymph node ratio as a prognostic factor of recurrence in medullary thyroid cancer.PeerJ · 2023Article
- Establishment and validation of a nomogram model for predicting distant metastasis in medullary thyroid carcinoma: An analysis of the SEER database based on the AJCC 8th TNM staging system.Frontiers in endocrinology · 2023Article
- Genetic and clinical profiles of 160 papillary thyroid cancers with lateral neck lymph node metastasis.Frontiers in oncology · 2022Article
- Beyond N staging in colorectal cancer: Current approaches and future perspectives.Frontiers in oncology · 2022Review
- Construction and Validation of a Prediction Model for Identifying Clinical Risk Factors of Lateral Lymph Node Metastasis in Medullary Thyroid Carcinoma.International journal of general medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lymph node ratio (LNR) has been investigated as a prognostic factor in many different types of cancers, including differentiated thyroid cancer; however, reports regarding medullary thyroid cancer (MTC) are limited. Therefore, this study aims to evaluate LNR as a risk factor for structural recurrence in patients with MTC. Medical records of patients treated for MTC in a single tertiary center between 1995 and 2017 were retrospectively reviewed. LNR is defined as the number of metastatic lymph nodes or lymph node metastases (LNM) divided by the number of retrieved lymph nodes or lymph node yield (LNY). In the survival analysis, recurrence-free survival was defined as the time from the date of total thyroidectomy to recurrence or last follow-up. To identify risk factors influencing structural recurrence, univariable and multivariable Cox proportional hazard models were used. A total of 132 patients were enrolled. The mean age of study participants was 49.7 years, and 86 patients (65%) were women. Structural recurrence was identified in 39 patients at the end of the study period, and the median follow-up period was 8.7 years. In univariable analyses, gross extra thyroidal extension, N stage, postoperative serum calcitonin and carcinoembryonic antigen (CEA) levels, and LNR were significant (
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