Evidence map›Paper›PMID 34830985›Full record

ArticleCancers2021

A Multicenter Epidemiological Study on Second Malignancy in Non-Syndromic Pheochromocytoma/Paraganglioma Patients in Italy.

Letizia Canu, Soraya Puglisi, Paola Berchialla, Giuseppina De Filpo, Francesca Brignardello, Francesca Schiavi, Alfonso Massimiliano Ferrara, Stefania Zovato, Michaela Luconi, Anna Pia and 24 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 11 institutions in 2 countries.

Letizia CanuDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50139 Florence, Italy.ORCID 0000-0003-4995-8108
Soraya PuglisiInternal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, 10043 Turin, Italy.ORCID 0000-0002-2883-6139
Paola BerchiallaStatistical Unit, Department of Clinical and Biological Sciences, University of Turin, Orbassano, 10143 Turin, Italy.ORCID 0000-0001-5835-5638
Giuseppina De FilpoDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50139 Florence, Italy.ORCID 0000-0003-1128-5526
Francesca BrignardelloInternal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, 10043 Turin, Italy.
Francesca SchiaviFamilial Cancer Clinic, Veneto Institute of Oncology IOV - IRCCS, 35128 Padua, Italy.
Alfonso Massimiliano FerraraFamilial Cancer Clinic, Veneto Institute of Oncology IOV - IRCCS, 35128 Padua, Italy.
Stefania ZovatoFamilial Cancer Clinic, Veneto Institute of Oncology IOV - IRCCS, 35128 Padua, Italy.
Michaela LuconiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50139 Florence, Italy.ORCID 0000-0001-5186-064X
Anna PiaInternal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, 10043 Turin, Italy.
Marialuisa AppetecchiaOncological Endocrinology Unit, IRCCS-Regina Elena National Cancer Institute, 00128 Rome, Italy.ORCID 0000-0002-2124-1335
Emanuela ArvatOncological Endocrinology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Claudio LetiziaSecondary Arterial Hypertension Unit, Department of Translational and Precision Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-4397-0624
Mauro MaccarioEndocrinology, Diabetology, and Metabolism Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Mirko Parasiliti-CaprinoEndocrinology, Diabetology, and Metabolism Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-6930-7073
Barbara AltieriDivision of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, 97080 Würzburg, Germany.ORCID 0000-0003-2616-3249
Antongiulio FaggianoEndocrinology, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0002-9324-3946
Roberta ModicaDivision of Endocrinology, Department of Clinical Medicine and Surgery, ENETS Center of Excellence, University "Federico II" of Naples, 80138 Naples, Italy.ORCID 0000-0002-3768-5803
Valentina MorelliEndocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.ORCID 0000-0002-6716-3045
Maura ArosioEndocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.ORCID 0000-0003-3988-3616
Uberta VergaEndocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.ORCID 0000-0002-3148-9123
Micaela PellegrinoDivision of Endocrinology, Diabetology and Metabolism, Santa Croce and Carle Hospital, 12100 Cuneo, Italy.
Luigi PetramalaSecondary Arterial Hypertension Unit, Department of Translational and Precision Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-4463-4956
Antonio ConcistrèSecondary Arterial Hypertension Unit, Department of Translational and Precision Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Paola RazzoreEndocrinology, Diabetology and Metabolism Diseases Unit, AO Ordine Mauriziano, 10128 Turin, Italy.
Tonino ErcolinoCentro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, 50134 Florence, Italy.
Elena RapizziCentro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, 50134 Florence, Italy.ORCID 0000-0002-3826-2714
Mario MaggiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50139 Florence, Italy.ORCID 0000-0003-3267-4221
Antonio StiglianoEndocrinology, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy.
Jacopo BurrelloDivision of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0001-7884-7314
Massimo TerzoloInternal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, 10043 Turin, Italy.ORCID 0000-0002-4171-2851
Giuseppe OpocherVeneto Institute of Oncology, IRCCS, 35128 Padua, Italy.
Massimo MannelliDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50139 Florence, Italy.ORCID 0000-0002-8001-9857
Giuseppe ReimondoInternal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, 10043 Turin, Italy.ORCID 0000-0001-9489-2094
Istituto Nazionale di Documentazione Innovazione e Ricerca Educativa · ITOspedale San Luigi Gonzaga · ITSapienza University of Rome · ITUniversity of Turin · ITIstituto Oncologico Veneto · ITUniversity of Milan · ITA. O. Ordine Mauriziano di Torino · ITAzienda Ospedaliero-Universitaria Careggi · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Florence · ITUniversity of Würzburg · DE

Funding

AIRC IG-2020-ID.24820MIUR Departments of Excellence 2018-2022Ricerca Locale Università di Torino 2020 RILO 2020
6 · The paper itself

Abstract

No studies have carried out an extensive analysis of the possible association between non-syndromic pheochromocytomas and paragangliomas (PPGLs) and other malignancies. To assess >the risk of additional malignancy in PPGL, we retrospectively evaluated 741 patients with PPGLs followed-up in twelve referral centers in Italy. Incidence of second malignant tumors was compared between this cohort and Italian patients with two subsequent malignancies. Among our patients, 95 (12.8%) developed a second malignant tumor, which were mainly prostate, colorectal and lung/bronchial cancers in males, breast cancer, differentiated thyroid cancer and melanoma in females. The standardized incidence ratio was 9.59 (95% CI 5.46-15.71) in males and 13.21 (95% CI 7.52-21.63) in females. At multivariable analysis, the risk of developing a second malignant tumor increased with age at diagnosis (HR 2.50, 95% CI 1.15-5.44,

Indexed as

epidemiologygenetic analysismortalityparagangliomapheochromocytomasurveillance

Identifiers

PMID34830985
PMCPMC8616182
OpenAlexW3216731143

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.