Evidence map›Paper›PMID 34830953›Full record

ArticleCancers2021

A Controlled Study of Major Depressive Episodes in Long-Term Childhood, Adolescence, and Young Adult Cancer Survivors (The NOR-CAYACS Study).

Alv A Dahl, Cecilie Essholt Kiserud, Sophie D Fosså, Jon Håvard Loge, Kristin Valborg Reinertsen, Ellen Ruud, Hanne C Lie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alv A DahlNational Advisory Unit on Late Effects after Cancer Treatment, Oslo University Hospital, 0424 Oslo, Norway.
Cecilie Essholt KiserudNational Advisory Unit on Late Effects after Cancer Treatment, Oslo University Hospital, 0424 Oslo, Norway.
Sophie D FossåNational Advisory Unit on Late Effects after Cancer Treatment, Oslo University Hospital, 0424 Oslo, Norway.
Jon Håvard LogeFaculty of Medicine, University of Oslo, 0316 Oslo, Norway.
Kristin Valborg ReinertsenNational Advisory Unit on Late Effects after Cancer Treatment, Oslo University Hospital, 0424 Oslo, Norway.
Ellen RuudFaculty of Medicine, University of Oslo, 0316 Oslo, Norway.
Hanne C LieNational Advisory Unit on Late Effects after Cancer Treatment, Oslo University Hospital, 0424 Oslo, Norway.
Oslo University Hospital · NOUniversity of Oslo · NO

Funding

Legacies of the Norwegian Radium Hospital 335007Norwegian Cancer Society 45480Norwegian Research Centre 218312
6 · The paper itself

Abstract

backgroundA major depressive episode (MDE) is typically self-rated by screening forms identifying probable MDE (pMDE). This population-based cross-sectional questionnaire study examined the prevalence rates of pMDE identified by the PHQ-9 screener in long-term survivors of childhood and adolescence (CACSs) and young adult cancer (YACSs) and a normative sample (NORMs).

methodsData from 488 CACSs, 1202 YACSs, and 1453 NORMs were analyzed, and pMDE was defined both by cut-off ≥10 on the total PHQ-9 score and by an algorithm.

resultsThe prevalence rates of pMDE among CACSs were 21.5%, 16.6% in YACSs, and 9.2% among NORMs using the cut-off definition. With the algorithm, the prevalence rates of pMDE were 8.0% among CACSs, 8.1% among YACSs, and 3.9% among NORMs. Independent of definition, CACSs and YACSs had significantly increased prevalence rates of pMDE compared to NORMs. Psychosocial factors and self-rated health were significantly associated with both definitions of pMDE in multivariable analyses, while survivor groups, cancer types, and adverse events were not.

conclusionSince pMDE has negative health consequences and is amenable to treatment, healthcare providers should be attentive and screen for pMDE in young cancer survivors. For PHQ-9, the preferred type of definition of pMDE should be determined.

Indexed as

cancer treatmentchildhood, adolescence and young adult cancer survivorscross-sectional studymajor depressive episodePHQ-9

Identifiers

PMID34830953
PMCPMC8616399
OpenAlexW3211610115

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.