Evidence map›Paper›PMID 34830941›Full record

ArticleCancers2021

Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer.

Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Hiroshi Yokozaki, Hiroki Sasaki

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  5. Article
  6. Review
  7. Article
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  9. Article
  10. Prognostic value of nicotinamide adenine dinucleotide (NADJournal of gastrointestinal oncology · 2022
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Shihori TanabeDivision of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences, Kawasaki 210-9501, Japan.ORCID 0000-0003-3706-0616
Sabina QuaderInnovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, Kawasaki 210-0821, Japan.ORCID 0000-0002-9616-7408
Ryuichi OnoDivision of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, Kawasaki 210-9501, Japan.
Horacio CabralDepartment of Bioengineering, Graduate School of Engineering, University of Tokyo, Tokyo 113-0033, Japan.
Kazuhiko AoyagiDepartment of Clinical Genomics, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
Akihiko HiroseDivision of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences, Kawasaki 210-9501, Japan.
Hiroshi YokozakiDepartment of Pathology, Kobe University of Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0001-5276-3331
Hiroki SasakiDepartment of Translational Oncology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
National Institute of Health Sciences · JPInnovation Center of NanoMedicine · JPKobe University · JPNational Cancer Centre Japan · JPThe University of Tokyo · JP

Funding

Japan Agency for Medical Research and Development JP21mk0101216Japan Society for the Promotion of Science 21K12133
6 · The paper itself

Abstract

Dynamic regulation in molecular networks including cell cycle regulation and DNA damage response play an important role in cancer. To reveal the feature of cancer malignancy, gene expression and network regulation were profiled in diffuse- and intestinal-type gastric cancer (GC). The results of the network analysis with Ingenuity Pathway Analysis (IPA) showed that the activation states of several canonical pathways related to cell cycle regulation were altered. The G

Indexed as

cancer malignancycell cycle regulationDNA damage responseepithelial-mesenchymal transition (EMT)gastric cancermolecular networknetwork analysis

Identifiers

PMID34830941
PMCPMC8616335
OpenAlexW3214462812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.