Evidence map›Paper›PMID 34830896›Full record

ArticleCancers2021

Stringent Base Specific and Optimization-Free Multiplex Mediator Probe ddPCR for the Quantification of Point Mutations in Circulating Tumor DNA.

Franziska Schlenker, Elena Kipf, Max Deuter, Inga Höffkes, Michael Lehnert, Roland Zengerle, Felix von Stetten, Florian Scherer, Julius Wehrle, Nikolas von Bubnoff and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Franziska SchlenkerHahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.ORCID 0000-0003-2082-1677
Elena KipfHahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.
Max DeuterDepartment of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0002-1055-4803
Inga HöffkesHahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.
Michael LehnertHahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.
Roland ZengerleHahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.
Felix von StettenHahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.ORCID 0000-0002-8547-0495
Florian SchererDepartment of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Julius WehrleDepartment of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0001-6514-4230
Nikolas von BubnoffDepartment of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0001-9593-8947
Peter JuelgHahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.
Tobias HutzenlaubHahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.
Nadine BorstHahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.ORCID 0000-0003-1258-3250
University of Freiburg · DEHahn-Schickard-Gesellschaft für angewandte Forschung · DE

Funding

Federal Ministry of Education and Research 13GW0198EFederal Ministry of Education and Research 13GW0198F
6 · The paper itself

Abstract

There is an increasing demand for optimization-free multiplex assays to rapidly establish comprehensive target panels for cancer monitoring by liquid biopsy. We present the mediator probe (MP) PCR for the quantification of the seven most frequent point mutations and corresponding wild types (

Indexed as

circulating tumor DNAcolorectal carcinomactDNAdigital PCRmediator probe PCRmultiplex PCRoptimization-freepoint mutationsstandardized universal reportertreatment response

Identifiers

PMID34830896
PMCPMC8616434
OpenAlexW3212546088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.