Evidence map›Paper›PMID 34830895›Full record

ArticleCancers2021

A Gene Signature Identifying CIN3 Regression and Cervical Cancer Survival.

Mari K Halle, Ane Cecilie Munk, Birgit Engesæter, Saleha Akbari, Astri Frafjord, Erling A Hoivik, David Forsse, Kristine E Fasmer, Kathrine Woie, Ingfrid S Haldorsen and 5 more

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Pancancer Analysis of RevealedDisease markers · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mari K HalleCentre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5053 Bergen, Norway.ORCID 0000-0002-2660-8271
Ane Cecilie MunkDepartment of Obstetrics and Gynaecology, Sørlandet Hospital Kristiansand, 4604 Kristiansand, Norway.
Birgit EngesæterSection for Cervical Cancer Screening, Cancer Registry of Norway, 0304 Oslo, Norway.ORCID 0000-0002-0956-8378
Saleha AkbariDepartment of Pathology, Stavanger University Hospital, 4068 Stavanger, Norway.
Astri FrafjordDepartment of Pathology, Stavanger University Hospital, 4068 Stavanger, Norway.ORCID 0000-0001-7942-1411
Erling A HoivikCentre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5053 Bergen, Norway.
David ForsseCentre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5053 Bergen, Norway.
Kristine E FasmerSection for Radiology, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway.
Kathrine WoieDepartment of Obstetrics and Gynaecology, Haukeland University Hospital, 5053 Bergen, Norway.
Ingfrid S HaldorsenSection for Radiology, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway.ORCID 0000-0001-9313-7564
Bjørn I BertelsenDepartment of Pathology, Haukeland University Hospital, 5021 Bergen, Norway.
Emiel A M JanssenDepartment of Pathology, Stavanger University Hospital, 4068 Stavanger, Norway.ORCID 0000-0002-7760-5396
Einar GudslaugssonDepartment of Pathology, Stavanger University Hospital, 4068 Stavanger, Norway.
Camilla KrakstadCentre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5053 Bergen, Norway.ORCID 0000-0002-0174-8139
Irene T ØvestadDepartment of Pathology, Stavanger University Hospital, 4068 Stavanger, Norway.

Funding

Folke Hermansen Year 2017-2019Norwegian Cancer Society 190202The Research Council of Norway 273280University of Bergen AnnualWestern Norway Regional Health Authority 27804 and 911634
6 · The paper itself

Abstract

The purpose of this study was to establish a gene signature that may predict CIN3 regression and that may aid in selecting patients who may safely refrain from conization. Oncomine mRNA data including 398 immune-related genes from 21 lesions with confirmed regression and 28 with persistent CIN3 were compared. L1000 mRNA data from a cervical cancer cohort was available for validation (

Indexed as

CD38cervical cancercervical intraepithelial neoplasia (CIN)conizationgene expression analysesHPV testimmune activationLCKperforinprognostic biomarker

Identifiers

PMID34830895
PMCPMC8616457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.