ArticleCancers2021
Risk of Malignant Transformation in 3173 Subjects with Histopathologically Confirmed Oral Lichen Planus: A 33-Year Cohort Study in Northern Italy.
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Beyond Clinicopathological Criteria: A Practical Management Framework for Oral Lichen Planus.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Efficacy of Platelet-Rich Plasma Therapy in Oral Lichen Planus: A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Trajectory-aware risk stratification of oral lichen planus using a multimodal large language model: a longitudinal diagnostic accuracy study.Scientific reports · 2026Article
- Autoimmune Oral Mucosal Diseases in Older Patients: An Overview of Early Recognition and Management in the Primary Care Setting.Geriatrics (Basel, Switzerland) · 2026Review
- Translation and Validation of Thai Versions of the Chronic Oral Mucosal Disease Questionnaire-15 and Oral Lichen Planus Symptom Severity Measure.Oral diseases · 2026Article
- Longitudinal Analysis of Oral Potentially Malignant Disorder Conversion to Malignancy.The Laryngoscope · 2026Article
- Esophageal Lichen Planus-Contemporary Insights and Emerging Trends.Biomedicines · 2025Review
- Estimation of salivary myeloid-related protein (calprotectin) level in patients with oral lichen planus: a case-control study.Oral and maxillofacial surgery · 2025Article
- Mucoscopic Features of Oral Lichen Planus: A Retrospective Comparative Study with Inflammatory Mimickers.Diagnostics (Basel, Switzerland) · 2025Article
- The association between skin allergy testing and oral squamous cell carcinoma in oral lichen planus: a retrospective cohort study.Archives of dermatological research · 2025Article
- Crosstalk Between Keratinocytes and T Cells in Ulcerative Oral Mucosal Diseases: Mechanisms of Epithelial Dysfunction and Therapeutic Perspectives.Journal of inflammation research · 2025Review
- History of Breast Cancer in Patients with Oral Lichen Planus: A Case-Control Study.Journal of clinical medicine · 2024Article
- Oral Lichen Planus: A Narrative Review Navigating Etiologies, Clinical Manifestations, Diagnostics, and Therapeutic Approaches.Journal of clinical medicine · 2024Review
- Increased expression of keratin 17 in oral lichen planus and its correlation with disease severity.Journal of dental sciences · 2024Article
- Inflammatory cytokines mediating the effect of oral lichen planus on oral cavity cancer risk: a univariable and multivariable mendelian randomization study.BMC oral health · 2024Article
- Review
- Immunomethylomic profiles of long-term head and neck squamous cell carcinoma survivors on immune checkpoint inhibitors.Epigenomics · 2024Article
- Bidirectional Association between Lichen Planus and Hepatitis C-An Update Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Characteristics of Clinically Classified Oral Lichen Planus in Optical Coherence Tomography: A Descriptive Case-Series Study.Diagnostics (Basel, Switzerland) · 2023Article
- CD8eLife · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral lichen planus (OLP) is considered an oral potentially malignant disorder. The aim of our study was to estimate the risk for oral cancer in patients diagnosed with OLP.
methodsA population-based cohort study between January 1988 and December 2020 at one hospital in Northern Italy was performed. The primary endpoint of the study was that of the histopathological diagnosis of oral cancer during the follow-up period.
resultsThe study population comprised 3173 patients. During the follow-up period, 32 men and 50 women developed an oral squamous cell carcinoma (2.58%), with a mean time of 103.61 months after the initial diagnosis of OLP, and 21 patients died because of oral cancer. Almost half of the deceased patients had the last follow-up visit before cancer diagnosis in a period of more than 12 months. Older age, having a red form of OLP and fewer sites of involvement, increased the risk of having cancer, while age and no treatment increased the risk of death.
conclusionThis is the largest group of OLP patients with such a long follow up ever reported. Due to the increased risk of having a malignant transformation, especially in elderly subjects, OLP patients should be regularly followed up, particularly in the Northern Italian population.
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