Evidence map›Paper›PMID 34830867›Full record

ArticleCancers2021

Diagnostic and Prognostic Implications of Caspase-1 and PD-L1 Co-Expression Patterns in Myelodysplastic Syndromes.

Johannes R Graf, Stefan Forster, Frido K Bruehl, Yara Banz, Mahmoud Hallal, Justine Brodard, Vera Ulrike Bacher, Ramanjaneyulu Allam, Christian M Schürch, Nicolas Bonadies

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Inflammasomes-New Contributors to Blood Diseases.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Johannes R GrafDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Stefan ForsterDepartment for BioMedical Research, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0003-3008-3268
Frido K BruehlInstitute of Pathology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Yara BanzInstitute of Pathology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Mahmoud HallalDepartment for BioMedical Research, University of Bern, 3010 Bern, Switzerland.
Justine BrodardDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0003-0970-7048
Vera Ulrike BacherDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0001-8771-947X
Ramanjaneyulu AllamDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0002-2789-3596
Christian M SchürchInstitute of Pathology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0002-1792-1768
Nicolas BonadiesDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0001-8761-2066
University of Bern · CH

Funding

Swiss Cancer Research HSR-4085-11-2016
6 · The paper itself

Abstract

backgroundThe inflammasome plays an essential role in lower risk MDS and immune subversion, with the up-regulation of immune checkpoint molecules in the progression to higher-risk disease. In this study, we explored the utility of immune-related biomarkers for the diagnosis and prognosis of MDS.

methodsWe performed an exploratory, case-control study with 20 randomly selected MDS patients and nine controls with non-inflammatory (

resultsIn multivariate analysis, we observed significant differences for Casp1 but not PD1/PD-L1 expression in our four conditions (

conclusionWe identified characteristic discordant co-expression patterns in lower- (Casp1

Indexed as

diagnosisimmune check-pointimmune-related biomarkersinflammasomemyelodysplastic syndromespersonalized treatmentprognosis

Identifiers

PMID34830867
PMCPMC8616142
OpenAlexW3214250126

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.