ReviewCancers2021
Fracture Risk Evaluation of Bone Metastases: A Burning Issue.
Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- [Differential diagnoses of malignant bone marrow diseases].Radiologie (Heidelberg, Germany) · 2026Review
- A three-dimensional finite element-based biomechanical properties analysis of the 10th thoracic vertebra invaded by bone metastases for clinical procedure optimization.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Beyond SINS: A Critical Review of Biomechanical, Microstructural, and Radiomic Biomarkers for Predicting Fracture Risk in Spinal Metastases.Diagnostics (Basel, Switzerland) · 2026Review
- Clinical and geriatric factors associated with fracture risk in older adults with bone metastases: A prospective observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Femur Fracture Risk Assessment in Patients with Lytic Metastases Using CT-Based Finite Element Models and Bone Crack Simulations Technique.Annals of biomedical engineering · 2026Article
- Enhancing bone metastasis CT report analysis: a comparison of local and proprietary large language models for privacy and resource efficiency.BMC health services research · 2026Article
- Metastatic Spine Disease Alters Vertebral Load-To-Strength Ratios in Cancer Patients Compared to Healthy Individuals.JOR spine · 2026Article
- Radiomics in spinal research: a narrative review.Frontiers in bioengineering and biotechnology · 2026Review
- Localized bone deterioration predicts declining failure load and increased fracture risk.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Incidence of frailty-related fracture among Medicaid beneficiaries living with HIV and cancer: A cohort study.PloS one · 2026Article
- The risk of pathological fractures after intralesional curettage in Atypical Cartilaginous Tumours: A retrospective cohort study.Journal of bone oncology · 2025Article
- Incidence of frailty-related fracture among Medicaid beneficiaries living with HIV and cancer: A cohort study.medRxiv : the preprint server for health sciences · 2025Article
- Review
- Are we underestimating pathological fracture risk in malignant bone lesions of the proximal humerus?Skeletal radiology · 2025Article
- Epidemiology of bone metastasis in France between 2009 and 2018.JBMR plus · 2025Article
- Biomimetic structural design in 3D-printed scaffolds for bone tissue engineering.Materials today. Bio · 2025Review
- Prognostic assessment of osteolytic lesions and mechanical properties of bones bearing breast cancer using neural network and finite element analysisMechanobiology in medicine · 2025Article
- Poroelastic Characterization of Human Vertebral Metastases to Inform a Transdisciplinary Assessment of Spinal Tumors.Journal of clinical medicine · 2025Article
- Bone Effects of Anti-Cancer Treatments in 2024.Calcified tissue international · 2025Review
- Bone metastases from endocrine cancer: advances in diagnosis, treatment, and prevention.Frontiers in endocrinology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major progress has been achieved to treat cancer patients and survival has improved considerably, even for stage-IV bone metastatic patients. Locomotive health has become a crucial issue for patient autonomy and quality of life. The centerpiece of the reflection lies in the fracture risk evaluation of bone metastasis to guide physician decision regarding physical activity, antiresorptive agent prescription, and local intervention by radiotherapy, surgery, and interventional radiology. A key mandatory step, since bone metastases may be asymptomatic and disseminated throughout the skeleton, is to identify the bone metastasis location by cartography, especially within weight-bearing bones. For every location, the fracture risk evaluation relies on qualitative approaches using imagery and scores such as Mirels and spinal instability neoplastic score (SINS). This approach, however, has important limitations and there is a need to develop new tools for bone metastatic and myeloma fracture risk evaluation. Personalized numerical simulation qCT-based imaging constitutes one of these emerging tools to assess bone tumoral strength and estimate the femoral and vertebral fracture risk. The next generation of numerical simulation and artificial intelligence will take into account multiple loadings to integrate movement and obtain conditions even closer to real-life, in order to guide patient rehabilitation and activity within a personalized-medicine approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.