Evidence map›Paper›PMID 34830833›Full record

ReviewCancers2021

Impact of Chromatin Dynamics and DNA Repair on Genomic Stability and Treatment Resistance in Pediatric High-Grade Gliomas.

Lia Pinto, Hanane Baidarjad, Natacha Entz-Werlé, Eric Van Dyck

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Association of RNA mBioMed research international · 2023
    Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Lia PintoDNA Repair and Chemoresistance, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg.
Hanane BaidarjadDNA Repair and Chemoresistance, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg.ORCID 0000-0002-2784-1403
Natacha Entz-WerléUMR CNRS 7021, Laboratory Bioimaging and Pathologies, Tumoral Signaling and Therapeutic Targets, Faculty of Pharmacy, 67401 Illkirch, France.
Eric Van DyckDNA Repair and Chemoresistance, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg.ORCID 0000-0001-8614-2402
University of Luxembourg · LUCentre National de la Recherche Scientifique · FRLuxembourg Institute of Health · LU

Funding

Action Lions "Vaincre le Cancer", Luxembourg Grant to H.B and E.V.DAFR/FNR, Luxembourg PhD fellowship to H.B.PRIDE/FNR PhD fellowhip to L.PTélévie/Fonds National de la Recherche (F.R.S.-FNRS)/Fonds National de la Recherche du Luxembourg (FNR) grants 7.4503.11 and 7.4633.16
6 · The paper itself

Abstract

Despite their low incidence, pediatric high-grade gliomas (pHGGs), including diffuse intrinsic pontine gliomas (DIPGs), are the leading cause of mortality in pediatric neuro-oncology. Recurrent, mutually exclusive mutations affecting K27 (K27M) and G34 (G34R/V) in the N-terminal tail of histones H3.3 and H3.1 act as key biological drivers of pHGGs. Notably, mutations in H3.3 are frequently associated with mutations affecting

Indexed as

alternative lengthening of telomere (ALT)ATRXchemoresistancechromatin dynamicsDAXXDNA repairgenomic instabilitypediatric high-grade gliomas(peri)centromeresynthetic lethalitytelomerasetelomerevariant H3.3 histone

Identifiers

PMID34830833
PMCPMC8616465
OpenAlexW3212674457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.