Evidence map›Paper›PMID 34830829›Full record

ArticleCancers2021

Cognitive Impairment in Long-Term Survivors of Testicular Cancer More Than 20 Years after Treatment.

Johannes Stelwagen, Andrea T Meuleman, Sjoukje Lubberts, Gerrie Steursma, Lara M Kruyt, Jan W Donkerbroek, Coby Meijer, Annemiek M E Walenkamp, Joop D Lefrandt, Sandra E Rakers and 9 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02572934 active not recruitingnot on this map

Health Status and Burden of Late Effects in Very Long-term Testicular Cancer Survivors (STANDBY-study)

TypeobservationalSponsorUniversity Medical Center GroningenRan2015 to 2026Enrolled281ConditionsTesticular Cancer
NCT07755839 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

CanCOG® - Cognitive Rehabilitation in Cancer: A Protocol for a Multicenter Pilot Randomized Controlled Trial With Non-central Nervous System Cancer Survivors

TypeinterventionalSponsorAveiro UniversityRan2026 to 2028Enrolled60ConditionsCancer-related Cognitive Impairment, Cancer-related Cognitive Dysfunction, Cancer-related Cognitive Difficulties, Depression and Anxiety SymptomsArmsCanCOG® - Cogntive Rehabilitation in Cancer
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Cancer treatment-related cognitive impairment.Neuro-oncology advances · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Psychological Outcomes in Adolescent and Young Adult Cancer Survivors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Johannes StelwagenDepartment of Medical Oncology, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Andrea T MeulemanDepartment of Medical Oncology, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Sjoukje LubbertsDepartment of Medical Oncology, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Gerrie SteursmaDepartment of Medical Oncology, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Lara M KruytDepartment of Medical Oncology, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Jan W DonkerbroekDepartment of Medical Oncology, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Coby MeijerDepartment of Medical Oncology, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Annemiek M E WalenkampDepartment of Medical Oncology, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Joop D LefrandtDepartment of Internal Medicine, Division of Vascular Medicine, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Sandra E RakersDepartment of Neuropsychology, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Rients B HuitemaDepartment of Neuropsychology, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Marianne A A de JongDepartment of Radiotherapy, Radiotherapeutic Institute Friesland, 8900 CC Leeuwarden, The Netherlands.
Erwin M WiegmanDepartment of Radiotherapy, Isala Hospital, 8025 AB Zwolle, The Netherlands.
Alfons C M van den BerghDepartment of Radiotherapy, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Igle J de JongDepartment of Urology, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Joost A Agelink van RentergemDepartment of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, 1018 WV Amsterdam, The Netherlands.
Sanne B SchagenDepartment of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, 1018 WV Amsterdam, The Netherlands.
Janine NuverDepartment of Medical Oncology, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.
Jourik A GietemaDepartment of Medical Oncology, University Medical Center Groningen and University of Groningen, 9728 NT Groningen, The Netherlands.ORCID 0000-0003-0629-7354
University Medical Center Groningen · NLThe Netherlands Cancer Institute · NLIsala · NLRadiotherapeutisch Instituut Friesland · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImpaired cognition can be a late effect after treatment in long-term testicular cancer (TC) survivors, negatively affecting their daily life. However, little data is available beyond 20 years post-treatment. We assessed cognitive impairment in very long-term TC survivors after CT or RT and compared the results with stage I TC survivors and controls.

methodsIn this cross-sectional multicenter cohort study, we enrolled TC survivors (treated with orchiectomy followed by CT or RT or orchiectomy only)-with a follow-up duration ≥ 20 years-and age-matched healthy controls. Cognitive testing included the Auditory Verbal Learning Test, Letter Fluency Test, Category Fluency Test, and Trail Making Test. We used fasting blood samples to assess the presence of hypogonadism and measured cardiovascular aging parameters, including carotid pulse wave velocity (c-PWV) and advanced glycation end products (AGEs).

resultsWe included 184 TC survivors (66 CT patients, 53 RT patients, and 65 orchiectomy-only patients) and 70 healthy controls. The median follow-up was 26 years (range: 20-42). TC survivors had a lower combined score of the cognitive tests (mean cumulative Z-score -0.85; 95% CI -1.39 to -0.33) compared to controls (mean 0.67; 95% CI -0.21 to 1.57,

conclusionsLong-term TC survivors performed worse on cognitive tests compared to controls. Physicians and patients should be informed about timely cardiovascular risk management and testosterone supplementation therapy during follow-up to reduce the risk of cognitive impairment.

trial registrationNCT02572934.

Indexed as

cancer survivorslate toxicityneurocognitive impairmenttesticular cancer

Identifiers

PMID34830829
PMCPMC8616311
OpenAlexW3212074386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.