Evidence map›Paper›PMID 34830738›Full record

ArticleJournal of clinical medicine2021

Low Brachial Artery Flow-Mediated Dilation Predicts Worse Prognosis in Hospitalized Patients with COVID-19.

Vanessa Bianconi, Massimo Raffaele Mannarino, Filippo Figorilli, Elisabetta Schiaroli, Elena Cosentini, Giuseppe Batori, Ettore Marini, Amirhossein Sahebkar, Francesco Grignani, Anna Gidari and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  7. Distinct Features of Vascular Diseases in COVID-19.Journal of inflammation research · 2023
    Review
  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Vanessa BianconiUnit of Internal Medicine, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy.
Massimo Raffaele MannarinoUnit of Internal Medicine, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy.ORCID 0000-0003-4694-5504
Filippo FigorilliUnit of Internal Medicine, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy.
Elisabetta SchiaroliUnit of Infectious Diseases, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy.
Elena CosentiniUnit of Internal Medicine, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy.
Giuseppe BatoriUnit of Internal Medicine, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy.
Ettore MariniUnit of Internal Medicine, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy.
Amirhossein SahebkarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 1696700, Iran.ORCID 0000-0002-8656-1444
Francesco GrignaniUnit of Internal Medicine, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy.
Anna GidariUnit of Infectious Diseases, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy.ORCID 0000-0002-6556-6553
Daniela FrancisciUnit of Infectious Diseases, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy.
Matteo PirroUnit of Internal Medicine, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy.
University of Perugia · ITMashhad University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndothelial injury can be induced by coronavirus disease 2019 (COVID-19) and seems to exert a crucial pathogenic role in its most severe clinical manifestations. We aimed to investigate the association between brachial artery flow-mediated dilation (bFMD), a potential clinical and non-invasive measure of endothelial function, and in-hospital prognosis of COVID-19 patients.

methodsBrachial artery flow-mediated dilation was assessed in hospitalized COVID-19 patients within 48 h of hospital admission. The association between bFMD and either intensive care unit (ICU) admission or in-hospital death was explored using univariable and multivariable analyses.

resultsFour hundred and eight patients were enrolled. Significantly lower bFMD values emerged in COVID-19 patients with either radiographic signs of pneumonia, respiratory distress, or the need for non-invasive ventilation compared with patients without these signs (

conclusionsLow bFMD predicts an unfavorable in-hospital prognosis in COVID-19 patients. The measurement of bFMD may be clinically useful in the prognostic stratification of COVID-19 patients upon hospital admission.

Indexed as

bFMDCOVID-19endothelial dysfunctionpneumoniaSARS-CoV-2

Identifiers

PMID34830738
PMCPMC8621380
OpenAlexW3217167216

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.