Evidence map›Paper›PMID 34830700›Full record

ArticleJournal of clinical medicine2021

Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study.

Anna Waśkiel-Burnat, Anna Niemczyk, Leszek Blicharz, Paulina Chmielińska, Michał Zaremba, Aleksandra Gąsecka, Krzysztof J Filipiak, Małgorzata Olszewska, Lidia Rudnicka

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
  5. Article
  6. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Anna Waśkiel-BurnatDepartment of Dermatology, Medical University of Warsaw, 02-008 Warsaw, Poland.
Anna NiemczykDepartment of Dermatology, Medical University of Warsaw, 02-008 Warsaw, Poland.
Leszek BlicharzDepartment of Dermatology, Medical University of Warsaw, 02-008 Warsaw, Poland.
Paulina ChmielińskaDepartment of Dermatology, Medical University of Warsaw, 02-008 Warsaw, Poland.
Michał ZarembaDepartment of Dermatology, Medical University of Warsaw, 02-008 Warsaw, Poland.ORCID 0000-0002-3211-4278
Aleksandra Gąsecka1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.ORCID 0000-0001-5083-7587
Krzysztof J FilipiakInstitute of Clinical Sciences, Maria Sklodowska-Curie Medical Academy, Pałac Lubomirskich, Plac Żelaznej Bramy 10, 00-136 Warsaw, Poland.ORCID 0000-0002-6563-0877
Małgorzata OlszewskaDepartment of Dermatology, Medical University of Warsaw, 02-008 Warsaw, Poland.
Lidia RudnickaDepartment of Dermatology, Medical University of Warsaw, 02-008 Warsaw, Poland.
Medical University of Warsaw · PLMaria Curie-Skłodowska University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to evaluate the serum concentrations of proinflammatory proteins associated with atherosclerosis (chemokine C-C motif ligand 4; CCL4, chemokine C-C motif ligand 7, CCL7; and sortilin, SORT1), and cardiovascular risk (myeloperoxidase, MPO; interleukin 1 receptor-like 1, IL1RL1; and growth differentiation factor 15, GDF15) in patients with alopecia areata without symptoms or prior cardiovascular disease in comparison with healthy controls. Sixty otherwise healthy patients with alopecia areata and twenty control subjects matched for age, gender, and body mass index (BMI) were enrolled in the study. No significant differences in the serum levels of MPO, IL1RL1, CCL4, CCL7, SORT1, and GDF15 were detected between patients with alopecia areata and healthy controls. A positive correlation was found between the serum concentration of CCL7 and the severity of alopecia areata (r = 0.281,

Indexed as

cardiovascular diseasecoronary artery diseasehair lossheart diseasemyocardial infarctionperipheral arterial diseasestroke

Identifiers

PMID34830700
PMCPMC8624305
OpenAlexW3217696076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.