Evidence map›Paper›PMID 34830660›Full record

ReviewJournal of clinical medicine2021

TEG

Gert Jacobus Laubscher, Petrus Johannes Lourens, Chantelle Venter, Douglas B Kell, Etheresia Pretorius

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Low-intensity ultrasound lysis of amyloid microclots in a lab-on-chip model.Frontiers in bioengineering and biotechnology · 2025
    Article
  10. Article
  11. Article
  12. Observational
  13. Diagnostic potential of blood plasma longitudinal viscosity measured using Brillouin light scattering.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Gert Jacobus LaubscherMediclinic Stellenbosch, Stellenbosch 7600, South Africa.
Petrus Johannes LourensMediclinic Stellenbosch, Stellenbosch 7600, South Africa.
Chantelle VenterDepartment of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch 7602, South Africa.ORCID 0000-0002-3067-8184
Douglas B KellDepartment of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch 7602, South Africa.ORCID 0000-0001-5838-7963
Etheresia PretoriusDepartment of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch 7602, South Africa.ORCID 0000-0002-9108-2384
Stellenbosch University · ZAUniversity of Liverpool · GB

Funding

Novo Nordisk Foundation grant NNF20CC0035580
6 · The paper itself

Abstract

An important component of severe COVID-19 disease is virus-induced endothelilitis. This leads to disruption of normal endothelial function, initiating a state of failing normal clotting physiology. Massively increased levels of von Willebrand Factor (VWF) lead to overwhelming platelet activation, as well as activation of the enzymatic (intrinsic) clotting pathway. In addition, there is an impaired fibrinolysis, caused by, amongst others, increased levels of alpha-(2) antiplasmin. The end result is hypercoagulation (proven by thromboelastography

Indexed as

blood clottingconsumptive coagulopathyCOVID-19fibrinolysisplateletsvon Willebrand factor

Identifiers

PMID34830660
PMCPMC8621180
OpenAlexW3214609464

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.