Evidence map›Paper›PMID 34830617›Full record

ReviewJournal of clinical medicine2021

What We Know about the Long-Term Risks of Hysterectomy for Benign Indication-A Systematic Review.

Obianuju Sandra Madueke-Laveaux, Amro Elsharoud, Ayman Al-Hendy

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06298110 (The Effect of PRP on Wound Healing in High Risk Patients Undergoing Abdominal Hysterectomy), which is not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06298110 phase2 / phase3unknown statusnot on this mapstarted 2024, after this paper: background citation

The Effect of PRP on Wound Healing in High Risk Patients Undergoing Abdominal Hysterectomy

TypeinterventionalSponsorHelwan UniversityRan2024 to 2024Enrolled80ConditionsWound Heal, Abdominal Wound, PRPArmsPlatelets Rich plasma of the same patient
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Contemporary Management of Uterine Fibroids.Journal of clinical medicine · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Sexual and reproductive health matters · 2025
    Article
  13. Article
  14. Modeling Uterine Fibroids Using Bioengineered Hydrogels.ACS biomaterials science & engineering · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Unilateral Oophorectomy and Age at Natural Menopause: A Longitudinal Community-Based Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Obianuju Sandra Madueke-LaveauxDepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.
Amro ElsharoudDepartment of Family Medicine, Texas Tech University Health and Science Center, Lubbock, TX 79430, USA.
Ayman Al-HendyDepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-8778-4447
University of Chicago · USTexas Tech University · US

Funding

Hypovitaminosis D promotes MED12-associated genomic instability in uterine fibroidsR01HD094378 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AL-HENDY, AYMAN, BOYER, THOMAS G · 2018 to 2022
$4.2M
NICHD NIH HHS R01 HD094378
6 · The paper itself

Abstract

Hysterectomy is the most common treatment option in women with uterine fibroids, providing definitive relief from the associated burdensome symptoms. As with all surgical interventions, hysterectomy is associated with risk of complications, short-term morbidities, and mortality, all of which have been described previously. However, information on the potential long-term risks of hysterectomy is only recently becoming available. A systematic literature review was performed to identify studies published between 2005 and December 2020 evaluating the long-term impact of hysterectomy on patient outcomes. A total of 29 relevant studies were identified. A review of the articles showed that hysterectomy may increase the risk of cardiovascular events, certain cancers, the need for further surgery, early ovarian failure and menopause, depression, and other outcomes. It is important to acknowledge that the available studies examine possible associations and hypotheses rather than causality, and there is a need to establish higher quality studies to truly evaluate the long-term consequences of hysterectomy. However, it is of value to consider these findings when discussing the benefits and risks of all treatment options with patients with uterine fibroids to allow for preference-based choices to be made in a shared decision-making process. This is key to ensuring that patients receive the treatment that best meets their individual needs.

Indexed as

adverse eventscomplicationslong-term consequences of hysterectomypatient engagementuterine fibroid managementuterine fibroids

Identifiers

PMID34830617
PMCPMC8622061
OpenAlexW3213343372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.