Evidence map›Paper›PMID 34830494›Full record

SynthesisInternational journal of molecular sciences2021

Effects of the

Francesca Carlini, Zaira Maroccia, Carla Fiorentini, Sara Travaglione, Alessia Fabbri

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Research Progress on perinatalFrontiers in microbiology · 2026
    Review
  3. Review
  4. Community Emergence of Cefixime-ResistantAntibiotics (Basel, Switzerland) · 2024
    Article
  5. The footprint of gut microbiota in gallbladder cancer: a mechanistic review.Frontiers in cellular and infection microbiology · 2024
    Review
  6. UropathogenicMicroorganisms · 2023
    Review
  7. Review
  8. Genetic heterogeneity of colorectal cancer and the microbiome.World journal of gastrointestinal oncology · 2023
    Review
  9. Review
  10. Article
  11. Review
  12. Characterization of DiarreaghenicAntibiotics (Basel, Switzerland) · 2022
    Article
  13. Article
  14. Frontiers in molecular biosciences · 2022
    Article
  15. Immunomodulatory properties of CNF1 toxin fromAmerican journal of cancer research · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francesca CarliniDepartment of Cardiovascular, Endocrine-Metabolic Diseases and Ageing, Istituto Superiore di Sanità, 00161 Rome, Italy.
Zaira MarocciaDepartment of Cardiovascular, Endocrine-Metabolic Diseases and Ageing, Istituto Superiore di Sanità, 00161 Rome, Italy.
Carla FiorentiniAssociazione Ricerca Terapie Oncologiche Integrate, ARTOI, 00165 Rome, Italy.ORCID 0000-0003-1707-6282
Sara TravaglioneDepartment of Cardiovascular, Endocrine-Metabolic Diseases and Ageing, Istituto Superiore di Sanità, 00161 Rome, Italy.
Alessia FabbriDepartment of Cardiovascular, Endocrine-Metabolic Diseases and Ageing, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-3075-3367

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytotoxic necrotizing factor 1 (CNF1) is a bacterial virulence factor, the target of which is represented by Rho GTPases, small proteins involved in a huge number of crucial cellular processes. CNF1, due to its ability to modulate the activity of Rho GTPases, represents a widely used tool to unravel the role played by these regulatory proteins in different biological processes. In this review, we summarized the data available in the scientific literature concerning the observed in vitro effects induced by CNF1. An article search was performed on electronic bibliographic resources. Screenings were performed of titles, abstracts, and full-texts according to PRISMA guidelines, whereas eligibility criteria were defined for in vitro studies. We identified a total of 299 records by electronic article search and included 76 original peer-reviewed scientific articles reporting morphological or biochemical modifications induced in vitro by soluble CNF1, either recombinant or from pathogenic

Indexed as

Actin CytoskeletonBacterial ToxinsCell LineEnterotoxinsEscherichia coliEscherichia coli InfectionsEscherichia coli ProteinsHumansrho GTP-Binding ProteinsBacterial Toxinscytotoxic necrotizing factor type 1EnterotoxinsEscherichia coli Proteinsrho GTP-Binding Proteinsactin cytoskeletonapoptosiscancer cell linecytotoxic necrotizing factor type 1mitochondriaprimary cell cultureRho GTP-binding proteinstransformed cell line

Identifiers

PMID34830494
PMCPMC8621085

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.