Evidence map›Paper›PMID 34830423›Full record

ArticleInternational journal of molecular sciences2021

New Investigations with Lupane Type A-Ring Azepane Triterpenoids for Antimycobacterial Drug Candidate Design.

Oxana Kazakova, Roxana Racoviceanu, Anastasiya Petrova, Marius Mioc, Adrian Militaru, Lucreția Udrescu, Mihai Udrescu, Adrian Voicu, Jason Cummings, Gregory Robertson and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. ACS infectious diseases · 2025
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Oxana KazakovaUfa Institute of Chemistry, The Ufa Federal Research Centre, The Russian Academy of Sciences, 71, Pr. Oktyabrya, 450054 Ufa, Russia.ORCID 0000-0002-5606-1588
Roxana RacoviceanuDepartment II-Pharmaceutical Chemistry, Faculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Sq., 300041 Timişoara, Romania.ORCID 0000-0002-3378-0774
Anastasiya PetrovaUfa Institute of Chemistry, The Ufa Federal Research Centre, The Russian Academy of Sciences, 71, Pr. Oktyabrya, 450054 Ufa, Russia.
Marius MiocDepartment II-Pharmaceutical Chemistry, Faculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Sq., 300041 Timişoara, Romania.
Adrian MilitaruDepartment of Computer and Information Technology, University Politehnica of Timişoara, 2 Vasile Pârvan Blvd., 300223 Timişoara, Romania.ORCID 0000-0003-4152-9122
Lucreția UdrescuDepartment I-Drug Analysis, Faculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Sq., 300041 Timişoara, Romania.ORCID 0000-0002-3084-6301
Mihai UdrescuDepartment of Computer and Information Technology, University Politehnica of Timişoara, 2 Vasile Pârvan Blvd., 300223 Timişoara, Romania.
Adrian VoicuDepartment III-Informatics and Medical Biostatistics, Faculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Sq., 300041 Timişoara, Romania.
Jason CummingsDepartment of Microbiology, Immunology & Pathology, Colorado State University, 1619 Campus Delivery, Fort Collins, CO 80523, USA.
Gregory RobertsonDepartment of Microbiology, Immunology & Pathology, Colorado State University, 1619 Campus Delivery, Fort Collins, CO 80523, USA.
Diane J OrdwayDepartment of Microbiology, Immunology & Pathology, Colorado State University, 1619 Campus Delivery, Fort Collins, CO 80523, USA.ORCID 0000-0003-0003-326X
Richard A SlaydenDepartment of Microbiology, Immunology & Pathology, Colorado State University, 1619 Campus Delivery, Fort Collins, CO 80523, USA.
Codruța ȘoicaDepartment II-Pharmaceutical Chemistry, Faculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Sq., 300041 Timişoara, Romania.

Funding

CLC NIH HHS 75N90019D00005
6 · The paper itself

Abstract

Twenty lupane type A-ring azepano-triterpenoids were synthesized from betulin and its related derivatives and their antitubercular activity against

Indexed as

Anti-Bacterial AgentsAntitubercular AgentsBetulinic AcidDNA-Directed RNA PolymerasesDrug DesignDrug Resistance, BacterialHumansMolecular Docking SimulationMolecular StructureMycobacterium tuberculosisPentacyclic TriterpenesRifampinTriterpenesTuberculosisAnti-Bacterial AgentsAntitubercular AgentsbetulinBetulinic AcidDNA-Directed RNA PolymeraseslupanePentacyclic TriterpenesRifampinRNA polymerase alpha subunitTriterpenesazepanebetulincytotoxicitylupaneM. abscessusM. aviumM. tuberculosisresistant MTB strainstriterpenoids

Identifiers

PMID34830423
PMCPMC8621456

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.