Evidence map›Paper›PMID 34830407›Full record

ArticleInternational journal of molecular sciences2021

Discrimination between 34 of 36 Possible Combinations of Three C>T SNP Genotypes in the

Katja Zappe, Christine Pirker, Heidi Miedl, Martin Schreiber, Petra Heffeter, Georg Pfeiler, Stefan Hacker, Werner Haslik, Sabine Spiegl-Kreinecker, Margit Cichna-Markl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. DNA Methylation and Transcript Variant Analysis ofInternational journal of molecular sciences · 2025
    Article
  2. Association of Intergenic and IntragenicInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Association ofCancers · 2023
    Article
  5. Association betweenCells · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Katja ZappeDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.
Christine PirkerDepartment of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.
Heidi MiedlComprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-4575-639X
Martin SchreiberComprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-1102-7789
Petra HeffeterDepartment of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.
Georg PfeilerDepartment of Obstetrics and Gynecology, Division of Gynecology and Gynecological Oncology, Medical University of Vienna, 1090 Vienna, Austria.
Stefan HackerDepartment of Plastic and Reconstructive Surgery, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-6376-4687
Werner HaslikDepartment of Obstetrics and Gynecology, Division of Gynecology and Gynecological Oncology, Medical University of Vienna, 1090 Vienna, Austria.
Sabine Spiegl-KreineckerDepartment of Neurosurgery, Medical Faculty, Kepler University Hospital GmbH, Johannes Kepler University Linz, 4040 Linz, Austria.ORCID 0000-0002-0553-834X
Margit Cichna-MarklDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-8699-674X
Comprehensive Cancer Center Vienna · ATMedical University of Vienna · ATUniversity of Vienna · ATFachhochschule Wiener Neustadt · ATKepler Universitätsklinikum · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to its cost-efficiency, high resolution melting (HRM) analysis plays an important role in genotyping of candidate single nucleotide polymorphisms (SNPs). Studies indicate that HRM analysis is not only suitable for genotyping individual SNPs, but also allows genotyping of multiple SNPs in one and the same amplicon, although with limited discrimination power. By targeting the three C>T SNPs rs527559815, rs547832288, and rs16906252, located in the promoter of the O6-methylguanine-DNA methyltransferase (

Indexed as

High-Throughput Nucleotide SequencingBreastDNA MethylationDNA Modification MethylasesDNA Repair EnzymesFemaleFreezingGenotypeGliomaHumansPolymorphism, Single NucleotidePromoter Regions, GeneticTumor Suppressor ProteinsDNA Modification MethylasesDNA Repair EnzymesMGMT protein, humanTumor Suppressor Proteinsgenotypinghigh resolution meltingMGMTmultiple SNPspyrosequencing

Identifiers

PMID34830407
PMCPMC8621402
OpenAlexW3214826336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.