Evidence map›Paper›PMID 34830405›Full record

ArticleInternational journal of molecular sciences2021

Knockout of the

Antonia Theodoridi, Alberto Dinarello, Lorenzo Badenetti, Michail Pavlidis, Luisa Dalla Valle, Aleka Tsalafouta

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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  14. Molecular Mechanisms Underlying Stress Response and Resilience.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Antonia TheodoridiDepartment of Biology, University of Crete, P.O. Box 2208, 714 09 Heraklion, Greece.
Alberto DinarelloDepartment of Biology, University of Padova, 35121 Padova, Italy.
Lorenzo BadenettiDepartment of Biology, University of Padova, 35121 Padova, Italy.
Michail PavlidisDepartment of Biology, University of Crete, P.O. Box 2208, 714 09 Heraklion, Greece.
Luisa Dalla ValleDepartment of Biology, University of Padova, 35121 Padova, Italy.ORCID 0000-0001-8097-6369
Aleka TsalafoutaDepartment of Biology, University of Crete, P.O. Box 2208, 714 09 Heraklion, Greece.
University of Crete · GRUniversity of Padua · IT

Funding

Hellenic Foundation for Research and Innovation 1169
6 · The paper itself

Abstract

The Hsd11b2 enzyme converts cortisol into its inactive form, cortisone and regulates cortisol levels, in particular in response to stress. Taking advantage of CRISPR/Cas9 technology, we generated a

Indexed as

11-beta-Hydroxysteroid Dehydrogenase Type 2AnimalsFemaleGene Knockout TechniquesHomozygoteHumansHydrocortisoneLarvaMaleStress, PhysiologicalZebrafish11-beta-Hydroxysteroid Dehydrogenase Type 2HydrocortisonecortisolCRISPR/Cas9glucocorticoidhsd11b2LMR-L/DstressVSRAzebrafish

Identifiers

PMID34830405
PMCPMC8619348
OpenAlexW3215451139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.