Evidence map›Paper›PMID 34830398›Full record

ReviewInternational journal of molecular sciences2021

Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?

Bilal Abdulmawjood, Beatriz Costa, Catarina Roma-Rodrigues, Pedro V Baptista, Alexandra R Fernandes

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Stem Cell Responsiveness to Imatinib in Chronic Myeloid Leukemia.International journal of molecular sciences · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. ExploringPharmaceutics · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bilal Abdulmawjoodi4HB-Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal.
Beatriz Costai4HB-Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal.
Catarina Roma-Rodriguesi4HB-Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal.ORCID 0000-0002-8676-6562
Pedro V Baptistai4HB-Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal.ORCID 0000-0001-5255-7095
Alexandra R Fernandesi4HB-Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal.ORCID 0000-0003-2054-4438
Unidade em Ciências Biomoleculares Aplicadas

Funding

Fundação para a Ciência e Tecnologia UIDP/04378/2020; UIDB/04378/2020
6 · The paper itself

Abstract

Chronic Myeloid Leukemia (CML) is a rare malignant proliferative disease of the hematopoietic system, whose molecular hallmark is the Philadelphia chromosome (Ph). The Ph chromosome originates an aberrant fusion gene with abnormal kinase activity, leading to the buildup of reactive oxygen species and genetic instability of relevance in disease progression. Several genetic abnormalities have been correlated with CML in the blast phase, including chromosomal aberrations and common altered genes. Some of these genes are involved in the regulation of cell apoptosis and proliferation, such as the epidermal growth factor receptor (

Indexed as

Philadelphia Chromosomebeta CateninBiomarkers, TumorBlast CrisisErbB ReceptorsGenomic InstabilityHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveProto-Oncogene Proteins pp60(c-src)Reactive Oxygen SpeciesTransforming Growth Factor beta1Tumor Suppressor Protein p53beta CateninBiomarkers, TumorCTNNB1 protein, humanEGFR protein, humanErbB ReceptorsProto-Oncogene Proteins pp60(c-src)Reactive Oxygen SpeciesTGFB1 protein, humanTP53 protein, humanTransforming Growth Factor beta1Tumor Suppressor Protein p53chronic myeloid leukemiagenetic biomarkersgenomic instabilitymiRNAsPhiladelphia chromosome

Identifiers

PMID34830398
PMCPMC8626020
OpenAlexW3214903373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.