Evidence map›Paper›PMID 34830392›Full record

ReviewInternational journal of molecular sciences2021

Stimuli-Responsive Polymeric Nanomaterials for the Delivery of Immunotherapy Moieties: Antigens, Adjuvants and Agonists.

Raveena Nagareddy, Reju George Thomas, Yong Yeon Jeong

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Observational
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Raveena NagareddyDepartment of Biomedical Sciences, Chonnam National University Hwasun Hospital, Hwasun 58128, Korea.ORCID 0000-0002-0252-7119
Reju George ThomasDepartment of Radiology, Chonnam National University Hwasun Hospital, Hwasun 58128, Korea.
Yong Yeon JeongDepartment of Radiology, Chonnam National University Hwasun Hospital, Hwasun 58128, Korea.

Funding

Korean government (MSIT) 2019M3E5D1A02068082National Research Foundation of Korea 2019M3E5D1A02068082
6 · The paper itself

Abstract

Immunotherapy has been investigated for decades, and it has provided promising results in preclinical studies. The most important issue that hinders researchers from advancing to clinical studies is the delivery system for immunotherapy agents, such as antigens, adjuvants and agonists, and the activation of these agents at the tumour site. Polymers are among the most versatile materials for a variety of treatments and diagnostics, and some polymers are reactive to either endogenous or exogenous stimuli. Utilizing this advantage, researchers have been developing novel and effective polymeric nanomaterials that can deliver immunotherapeutic moieties. In this review, we summarized recent works on stimuli-responsive polymeric nanomaterials that deliver antigens, adjuvants and agonists to tumours for immunotherapy purposes.

Indexed as

ImmunotherapyAdjuvants, ImmunologicAntigensHumansNanostructuresNeoplasmsPolymersAdjuvants, ImmunologicAntigensPolymerscancer immunotherapypolymer nanoparticlestimulitumour microenvironment (TME)

Identifiers

PMID34830392
PMCPMC8625613

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.