Evidence map›Paper›PMID 34830387›Full record

ArticleInternational journal of molecular sciences2021

RETRACTED: Neuroprotective Effect of Statins in a Rat Model of Chronic Ocular Hypertension.

Mi-Lyang Kim, Kyung Rim Sung, Junki Kwon, Go Woon Choi, Jin A Shin

RetractedErratum issuedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Wistar rat model experiments for increasing intraocular pressure: a systematic review.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Circumlimbal suture and laser burns: Comparison between two different chronic glaucoma models.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. New strategies for neuro protection in glaucoma.Frontiers in cell and developmental biology · 2022
    Review
  14. Statins on Spontaneous Intracerebral Hemorrhage: A Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mi-Lyang KimBiomedical Research Center, College of Medicine, University of Ulsan, Asan Medical Center, Seoul 05505, Korea.
Kyung Rim SungDepartment of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul 05505, Korea.
Junki KwonDepartment of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul 05505, Korea.
Go Woon ChoiBiomedical Research Center, College of Medicine, University of Ulsan, Asan Medical Center, Seoul 05505, Korea.
Jin A ShinBiomedical Research Center, College of Medicine, University of Ulsan, Asan Medical Center, Seoul 05505, Korea.
Asan Medical Center · KRUniversity of Ulsan · KR

Funding

National Research Foundation of Korea NRF-2017R1A2B4007792
6 · The paper itself

Abstract

Glaucoma is an optic neuropathy in which the degeneration of retinal ganglion cells (RGCs) results in irreversible vison loss. Therefore, neuroprotection of RGCs from glaucomatous afflictions is crucial for glaucoma treatment. In this study, we aimed to investigate the beneficial effects of statins in the protection of RGCs using a rat model. Glaucomatous injury was induced in rats by chronic ocular hypertension (OHT) achieved after performing a circumlimbal suture. The rats were given either statins such as simvastatin and atorvastatin or a solvent weekly for 6 weeks. Retina sections underwent hematoxylin and eosin, Brn3a, or cleaved casepase-3 staining to evaluate RGC survival. In addition, modulation of glial activation was assessed. While the retinas without statin treatment exhibited increased RGC death due to chronic OHT, statins promoted the survival of RGCs and reduced apoptosis. Statins also suppressed chronic OHT-mediated glial activation in the retina. Our results demonstrate that statins exert neuroprotective effects in rat retinas exposed to chronic OHT, which may support the prospect of statins being a glaucoma treatment.

Indexed as

AnimalsDisease Models, AnimalGlaucomaHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIntraocular PressureNeuroprotectionNeuroprotective AgentsOcular HypertensionOptic NerveOptic Nerve DiseasesRatsRetinaRetinal DegenerationRetinal Ganglion CellsTranscription Factor Brn-3AHydroxymethylglutaryl-CoA Reductase InhibitorsNeuroprotective AgentsPOU4F1 protein, humanTranscription Factor Brn-3Aglaucomaneuroprotectionocular hypertensionretinal ganglion cellstatin

Identifiers

PMID34830387
PMCPMC8621698
OpenAlexW3217749208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.