Evidence map›Paper›PMID 34830315›Full record

ArticleInternational journal of molecular sciences2021

In Vivo Renin Activity Imaging in the Kidney of Progeroid

Bibi S van Thiel, Janette van der Linden, Yanto Ridwan, Ingrid M Garrelds, Marcel Vermeij, Marian C Clahsen-van Groningen, Fatimunnisa Qadri, Natalia Alenina, Michael Bader, Anton J M Roks and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. SUL-138 mitigates accelerated endothelial aging and protects the kidney.Clinical science (London, England : 1979) · 2025
    Article
  2. Article
  3. Molecular Pathology, Diagnostics, and Therapeutics of Nephropathy.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Bibi S van ThielDepartment of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Janette van der LindenDepartment of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Yanto RidwanDepartment of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Ingrid M GarreldsDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Marcel VermeijDepartment of Pathology, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Marian C Clahsen-van GroningenDepartment of Pathology, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Fatimunnisa QadriMax Delbrück Center, 13125 Berlin, Germany.
Natalia AleninaMax Delbrück Center, 13125 Berlin, Germany.ORCID 0000-0002-6071-5433
Michael BaderMax Delbrück Center, 13125 Berlin, Germany.
Anton J M RoksDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
A H Jan DanserDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.ORCID 0000-0002-5052-3585
Jeroen EssersDepartment of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Ingrid van der PluijmDepartment of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Erasmus MC · NLMax Delbrück Center · DE

Funding

German Research Foundation DFG SFB1365 RenoprotectionLijf en Leven grant (2011): 'Dilating versus stenosing arterial disease (DIVERS) DIVERS 2011
6 · The paper itself

Abstract

Changes in the renin-angiotensin system, known for its critical role in the regulation of blood pressure and sodium homeostasis, may contribute to aging and age-related diseases. While the renin-angiotensin system is suppressed during aging, little is known about its regulation and activity within tissues. However, this knowledge is required to successively treat or prevent renal disease in the elderly. Ercc1 is involved in important DNA repair pathways, and when mutated causes accelerated aging phenotypes in humans and mice. In this study, we hypothesized that unrepaired DNA damage contributes to accelerated kidney failure. We tested the use of the renin-activatable near-infrared fluorescent probe ReninSense680™ in progeroid

Indexed as

AgingAngiotensin IIAngiotensin II Type 1 Receptor BlockersAnimalsDisease Models, AnimalDNA-Binding ProteinsDNA DamageDNA RepairEndonucleasesFemaleGene Expression RegulationGlomerular Filtration RateGlomerulosclerosis, Focal SegmentalHumansKidneyLosartanAngiotensin IIAngiotensin II Type 1 Receptor BlockersDNA-Binding ProteinsEndonucleasesErcc1 protein, mouseLosartanReninin vivo imagingrenal agingrenal diseasereninrenin-angiotensin system

Identifiers

PMID34830315
PMCPMC8619549
OpenAlexW3211982511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.