Evidence map›Paper›PMID 34830293›Full record

ArticleInternational journal of molecular sciences2021

MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.

Shuang Ge, Wei Yang, Haiqiang Chen, Qi Yuan, Shi Liu, Yongxiang Zhao, Jinhua Zhang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Single-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis.American journal of respiratory and critical care medicine · 2024
    Article
  6. Review
  7. METTL14 downregulation drives S100A4Signal transduction and targeted therapy · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Macrophage pathology in hepatotoxicity.Journal of toxicologic pathology · 2023
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Shuang GeNational Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning 530021, China.
Wei YangNational Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning 530021, China.
Haiqiang ChenCollege of Life Science and Bioengineering, Beijing Jiaotong University, Beijing 100044, China.
Qi YuanCollege of Life Science and Bioengineering, Beijing Jiaotong University, Beijing 100044, China.
Shi LiuCollege of Life Science and Bioengineering, Beijing Jiaotong University, Beijing 100044, China.
Yongxiang ZhaoNational Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning 530021, China.
Jinhua ZhangNational Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning 530021, China.ORCID 0000-0001-8957-8893
Guangxi Medical University · CNBeijing Jiaotong University · CN

Funding

Ministry of Science and Technology 2015CB553705National Natural Science Foundation of China 81772497National Natural Science Foundation of China 81972689
6 · The paper itself

Abstract

Chronic liver disease mediated by the activation of hepatic stellate cells (HSCs) leads to liver fibrosis. The signal adaptor MyD88 of Toll-like receptor (TLR) signaling is involved during the progression of liver fibrosis. However, the specific role of MyD88 in myeloid cells in liver fibrosis has not been thoroughly investigated. In this study, we used a carbon tetrachloride (CCl

Indexed as

AnimalsCarbon TetrachlorideCell LineChemokine CXCL2Coculture TechniquesDisease Models, AnimalFemaleGene DeletionHepatic Stellate CellsHumansInflammasomesLiver CirrhosisMacrophagesMaleMiceMice, Inbred C57BLCarbon TetrachlorideChemokine CXCL2Cxcl2 protein, mouseInflammasomesMyd88 protein, mouseMyeloid Differentiation Factor 88NLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNlrp3 protein, mouseHSCliver fibrosismacrophageMyD88NLRP3

Identifiers

PMID34830293
PMCPMC8622429
OpenAlexW3215900128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.