Evidence map›Paper›PMID 34830257›Full record

ArticleInternational journal of molecular sciences2021

Antiviral Effect of Lithium Chloride on Replication of Marek's Disease Virus in Chicken Embryonic Fibroblasts.

Huifeng He, Dandan Qiao, Lu Zhang, Yongxiu Yao, Hongxia Shao, Aijian Qin, Kun Qian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. A Protective Role of Canonical Wnt/Mediators of inflammation · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Huifeng HeMinistry of Education Key Lab for Avian Preventive Medicine, Yangzhou University, No. 48 East Wenhui Road, Yangzhou 225009, China.
Dandan QiaoJiangsu Key Lab of Preventive Veterinary Medicine, Yangzhou University, No. 48 East Wenhui Road, Yangzhou 225009, China.
Lu ZhangMinistry of Education Key Lab for Avian Preventive Medicine, Yangzhou University, No. 48 East Wenhui Road, Yangzhou 225009, China.
Yongxiu YaoThe Pirbright Institute & UK-China Centre of Excellence for Research on Avian Diseases, Pirbright, Surrey GU24 0NF, UK.
Hongxia ShaoMinistry of Education Key Lab for Avian Preventive Medicine, Yangzhou University, No. 48 East Wenhui Road, Yangzhou 225009, China.
Aijian QinMinistry of Education Key Lab for Avian Preventive Medicine, Yangzhou University, No. 48 East Wenhui Road, Yangzhou 225009, China.ORCID 0000-0001-5779-273X
Kun QianMinistry of Education Key Lab for Avian Preventive Medicine, Yangzhou University, No. 48 East Wenhui Road, Yangzhou 225009, China.ORCID 0000-0002-8900-1848
Yangzhou University · CNThe Pirbright Institute · GB

Funding

BSRC Newton Fund BB/R012865/1Jiangsu Agricultural independent innovation pro-ject CX(19)3008National Natural Science Foundation of China 31772734; 32072839NCFC-RCUK-BBSRC 31761133002
6 · The paper itself

Abstract

To investigate the antiviral effect of lithium chloride (LiCl) on the replication of Marek's disease virus (MDV) in chicken embryonic fibroblast (CEF) cells, real-time PCR, Western blotting, plaque counting, and indirect immunofluorescence experiments were performed at different time points of LiCl treated CEF cells with virus infection. The results demonstrated that LiCl could affect multiple steps of virus replication and inhibit viral gene expression and protein synthesis in a dose- and time-dependent manner. Moreover, LiCl could directly affect viral infectivity as well. In addition, LiCl significantly affected the gene expression of IFN-β related genes in virus-infected cells. These results indicate that LiCl significantly inhibits MDV replication and proliferation in CEF cells and it has the potential to be used as an antiviral agent against MDV.

Indexed as

2',5'-Oligoadenylate SynthetaseAnimalsAntiviral AgentsCell LineChick EmbryoChickensDose-Response Relationship, DrugFibroblastsGene Expression RegulationHerpesvirus 2, GallidHost-Pathogen InteractionsInterferon-betaInterferon Regulatory Factor-7Lithium ChlorideOncogene Proteins, ViralViral Load2',5'-Oligoadenylate SynthetaseAntiviral AgentsEco-Q protein, Gallid herpesvirus 2Interferon-betaInterferon Regulatory Factor-7Lithium ChlorideOncogene Proteins, Viralinhibitionlithium chlorideMarek’s disease virusvirus replication

Identifiers

PMID34830257
PMCPMC8623539
OpenAlexW3214343415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.