Evidence map›Paper›PMID 34830245›Full record

ReviewInternational journal of molecular sciences2021

Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation.

Sumika Toyama, Mitsutoshi Tominaga, Kenji Takamori

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Mechanisms of Itch in Atopic Dermatitis.Juntendo medical journal · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Uremic Pruritus: From Diagnosis to Treatment.Diagnostics (Basel, Switzerland) · 2022
    Review
  14. Frontiers in molecular neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sumika ToyamaJuntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Tomioka, Chiba 279-0021, Japan.ORCID 0000-0003-3606-245X
Mitsutoshi TominagaJuntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Tomioka, Chiba 279-0021, Japan.ORCID 0000-0002-1254-1803
Kenji TakamoriJuntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Tomioka, Chiba 279-0021, Japan.ORCID 0000-0002-0644-0504
Juntendo University · JP

Funding

Grant-in-Aid for Early-Career Scientists 19K17817and 21K16307Grant-in-Aid for Research Activity Start-up 17H07096Grant-in-Aid for Scientific Research (B) 20H03568The Inohana Foundation (Chiba University) Grant-in-Aid IFCU-2021-06
6 · The paper itself

Abstract

Although histamine is a well-known itch mediator, histamine H

Indexed as

Antibodies, MonoclonalAnti-Inflammatory AgentsCytokinesGene ExpressionHistamineHistamine AntagonistsHumansImmunologic FactorsLymphocytesMyeloid CellsNeuropeptidesPeptide HydrolasesProtease InhibitorsPruritusReceptors, Histamine H1Sensory Receptor CellsAntibodies, MonoclonalAnti-Inflammatory AgentsCytokinesHistamineHistamine AntagonistsImmunologic FactorsNeuropeptidesPeptide HydrolasesProtease InhibitorsReceptors, Histamine H1cytokinesimmune cellitch mediator and modulatorsensory neuron

Identifiers

PMID34830245
PMCPMC8624544
OpenAlexW3213141717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.