Evidence map›Paper›PMID 34830218›Full record

ArticleInternational journal of molecular sciences2021

NTRK Gene Fusion Detection in Atypical Spitz Tumors.

Rocco Cappellesso, Filippo Nozzoli, Federica Zito Marino, Sara Simi, Francesca Castiglione, Vincenzo De Giorgi, Carlo Cota, Rebecca Senetta, Giosuè Scognamiglio, Anna Maria Anniciello and 12 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Gene fusions in melanocytic lesions: an updated comprehensive review.Journal of pathology and translational medicine · 2026
    Article
  3. Article
  4. International journal of molecular sciences · 2024
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused byInternational journal of molecular sciences · 2022
    Article
  10. Review
  11. Conceptual Evolution and Current Approach to Spitz Tumors.Dermatopathology (Basel, Switzerland) · 2022
    Article
  12. The Morpho-Molecular Landscape of Spitz Neoplasms.International journal of molecular sciences · 2022
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 15 institutions in 1 country.

Rocco CappellessoPathological Anatomy Unit, University Hospital of Padua, 35121 Padua, Italy.ORCID 0000-0002-0480-3412
Filippo NozzoliSection of Anatomic Pathology, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Federica Zito MarinoPathology Unit, University of Campania "L. Vanvitelli", 80129 Naples, Italy.
Sara SimiSection of Anatomic Pathology, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Francesca CastiglioneSection of Anatomic Pathology, Careggi University Hospital, 50139 Florence, Italy.ORCID 0000-0003-1696-5651
Vincenzo De GiorgiDepartment of Dermatology, University of Florence, 50139 Florence, Italy.ORCID 0000-0001-6531-7998
Carlo CotaUnit of Dermatopathology, San Gallicano Dermatological Institute, 00153 Rome, Italy.
Rebecca SenettaPathology Unit, Department of Oncology, University of Turin, 10126 Turin, Italy.
Giosuè ScognamiglioPathology Unit, Istituto Nazionale Tumori-IRCCS -Fondazione G Pascale, 80131 Naples, Italy.
Anna Maria AnnicielloPathology Unit, Istituto Nazionale Tumori-IRCCS -Fondazione G Pascale, 80131 Naples, Italy.
Anna Maria CesinaroDepartment of Anatomic Pathology, Azienda Ospedaliero-Universitaria di Modena, 41122 Modena, Italy.
Mario MandalàUnit of Medical Oncology, University of Perugia, 06129 Perugia, Italy.ORCID 0000-0001-8846-8959
Andrea GianattiPathology Unit, ASST-Papa Giovanni XXIII, 24127 Bergamo, Italy.ORCID 0000-0003-2303-7394
Maria Gabriella ValenteDepartment of Pathology, San Gerardo Hospital, University of Milano-Bicocca, 20900 Monza, Italy.
Barbara ValeriDepartment of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, Italy.
Angela Rita SementaPathology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Costantino RicciPathology Unit, Ospedale Maggiore, 40133 Bologna, Italy.ORCID 0000-0001-7254-4195
Barbara CortiPathology Unit, IRCCS University Hospital of Bologna, 40133 Bologna, Italy.ORCID 0000-0001-6555-6227
Giandomenico RovielloDepartment of Health Sciences, University of Florence, 50139 Florence, Italy.
Angelo Paolo Dei TosPathological Anatomy Unit, University Hospital of Padua, 35121 Padua, Italy.
Renato FrancoPathology Unit, University of Campania "L. Vanvitelli", 80129 Naples, Italy.ORCID 0000-0002-8340-3184
Daniela MassiSection of Anatomic Pathology, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
University of Florence · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Padua · ITAzienda Ospedaliero-Universitaria Careggi · ITAzienda Ospedaliero-Universitaria di Modena · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITIstituto Giannina Gaslini · ITOspedale Papa Giovanni XXIII · ITSan Gallicano Hospital · ITUniversity of Bologna · ITUniversity of Milano-Bicocca · ITUniversity of Perugia · ITUniversity of Turin · IT

Funding

Bayer AG 0Diatech Pharmacogenetics 0
6 · The paper itself

Abstract

Atypical Spitz tumors (AST) deviate from stereotypical Spitz nevi for one or more atypical features and are now regarded as an intermediate category of melanocytic tumors with uncertain malignant potential. Activating

Indexed as

Oncogene FusionAdolescentAdultChildChild, PreschoolData AccuracyFemaleHigh-Throughput Nucleotide SequencingHumansImmunohistochemistryIn Situ Hybridization, FluorescenceMaleMiddle AgedNevus, Epithelioid and Spindle CellOncogene Proteins, FusionReal-Time Polymerase Chain ReactionNTRK1 protein, humanNTRK3 protein, humanOncogene Proteins, FusionReceptor, trkAReceptor, trkCatypical spitz tumorNTRKNTRK1NTRK3pan-TRK

Identifiers

PMID34830218
PMCPMC8619835
OpenAlexW3213687913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.