Evidence map›Paper›PMID 34830152›Full record

ReviewInternational journal of molecular sciences2021

Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation.

Jiaxiang Li, Jinmin Gao, Ruoxi Wang

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Stabilization of cyclin D3 protein by CDKN1A (p21Cell communication and signaling : CCS · 2026
    Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jiaxiang LiKey Laboratory of Animal Resistance Biology of Shandong Province, Institute of Biomedical Sciences, College of Life Sciences, Shandong Normal University, Jinan 250014, China.
Jinmin GaoKey Laboratory of Animal Resistance Biology of Shandong Province, Institute of Biomedical Sciences, College of Life Sciences, Shandong Normal University, Jinan 250014, China.
Ruoxi WangKey Laboratory of Animal Resistance Biology of Shandong Province, Institute of Biomedical Sciences, College of Life Sciences, Shandong Normal University, Jinan 250014, China.ORCID 0000-0002-8417-1987
Shandong Normal University · CN

Funding

China Postdoctoral Science Foundation Grant 2019M662431National Natural Science Foundation of China 31900557
6 · The paper itself

Abstract

Phase-separated condensates participate in various biological activities. Liquid-liquid phase separation (LLPS) can be driven by collective interactions between multivalent and intrinsically disordered proteins. The manner in which chromatin-with various morphologies and activities-is organized in a complex and small nucleus still remains to be fully determined. Recent findings support the claim that phase separation is involved in the regulation of chromatin organization and chromosome behavior. Moreover, phase separation also influences key events during mitosis and meiosis. This review elaborately dissects how phase separation regulates chromatin and chromosome organization and controls mitotic and meiotic chromosome behavior.

Indexed as

Cell CycleChromatin Assembly and DisassemblyAnimalsChromatinChromosomes, MammalianDNA-Binding ProteinsHumansIntrinsically Disordered ProteinsLiquid-Liquid ExtractionPhase TransitionChromatinDNA-Binding ProteinsIntrinsically Disordered Proteinschromosome organizationliquid-liquid phase separation (LLPS)meiosismitosis

Identifiers

PMID34830152
PMCPMC8621359
OpenAlexW3211636928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.