Evidence map›Paper›PMID 34830150›Full record

ArticleInternational journal of molecular sciences2021

Modulation of Neurolipid Signaling and Specific Lipid Species in the Triple Transgenic Mouse Model of Alzheimer's Disease.

Estibaliz González de San Román, Alberto Llorente-Ovejero, Jonatan Martínez-Gardeazabal, Marta Moreno-Rodríguez, Lydia Giménez-Llort, Iván Manuel, Rafael Rodríguez-Puertas

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Lysophospholipid receptors in neurodegeneration and neuroprotection.Exploration of neuroprotective therapy · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Estibaliz González de San RománDepartment of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.
Alberto Llorente-OvejeroDepartment of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.
Jonatan Martínez-GardeazabalDepartment of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.ORCID 0000-0002-0701-9076
Marta Moreno-RodríguezDepartment of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.ORCID 0000-0002-9980-9365
Lydia Giménez-LlortDepartment of Psychiatry and Forensic Medicine, Institute of Neuroscience, Faculty of Medicine, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.ORCID 0000-0002-4091-489X
Iván ManuelDepartment of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.
Rafael Rodríguez-PuertasDepartment of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.ORCID 0000-0003-4517-5114
University of the Basque Country · ESUniversitat Autònoma de Barcelona · ES

Funding

regional Basque Government IT975-16 to the "Neurochemistry and Neurodegeneration" consoli-dated research group IT975-16
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in aging populations. Recently, the regulation of neurolipid-mediated signaling and cerebral lipid species was shown in AD patients. The triple transgenic mouse model (3xTg-AD), harboring βAPP

Indexed as

Disease Models, AnimalSignal TransductionAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsBrainFatty Acids, UnsaturatedHippocampusHumansLipidsLysophospholipidsMaleMice, TransgenicPhospholipidsPresenilin-1Spectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAmyloid beta-Protein PrecursorFatty Acids, UnsaturatedLipidslysophosphatidic acidLysophospholipidsPhospholipidsPresenilin-1Sphingosinesphingosine 1-phosphatetau Proteins[35S]GTPγS autoradiography3xTg-AD miceAlzheimer’s diseasecannabinoid receptorsfunctional autoradiographyG proteinligand bindingLPA receptorsMALDI-MSIsphingosine 1-phosphate

Identifiers

PMID34830150
PMCPMC8620566
OpenAlexW3214026946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.