Evidence map›Paper›PMID 34830090›Full record

ArticleInternational journal of molecular sciences2021

Estradiol Protects against Noise-Induced Hearing Loss and Modulates Auditory Physiology in Female Mice.

Benjamin Shuster, Ryan Casserly, Erika Lipford, Rafal Olszewski, Béatrice Milon, Shaun Viechweg, Kanisa Davidson, Jennifer Enoch, Mark McMurray, Mark A Rutherford and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Ototoxicity prognostic models in adult and pediatric cancer patients: a rapid review.Journal of cancer survivorship : research and practice · 2023
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Benjamin ShusterDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Ryan CasserlyDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Erika LipfordDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Rafal OlszewskiAuditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA.
Béatrice MilonDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Shaun ViechwegDepartment of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Kanisa DavidsonDepartment of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Jennifer EnochDepartment of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Mark McMurrayDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Mark A RutherfordDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kevin K OhlemillerDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michael HoaAuditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA.
Didier A DepireuxOtolith Labs, Washington, DC 20036, USA.ORCID 0000-0002-7708-2660
Jessica A MongDepartment of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Ronna HertzanoDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USNational Institute on Deafness and Other Communication Disorders · USWashington University in St. Louis · USOtolith Labs (United States) · US

Funding

EXCITATION AND EXCITOTOXICITY IN TYPE I COCHLEAR AFFERENTS: SYNAPTIC STRUCTURE AND FUNCTIONR01DC014712 · NIDCD · WASHINGTON UNIVERSITY · PI Mark Allen Rutherford · 2016 to 2026
$5.6M
Cell Type Specific Transcriptional Cascades in Inner Ear DevelopmentR01DC013817 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI HERTZANO, RONNA · 2015 to 2022
$3.6M
Cell Type Specific Transcriptional Cascades in Inner Ear DevelopmentU01DC013817 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI AHMED, ZUBAIR M. · 2023 to 2025
$1.6M
EMBRYOLOGY OF THE INNER EARR01DC000088 · NIDCD · YESHIVA UNIVERSITY · PI VAN DE WATER, THOMAS R · 1989 to 1994
–
NIDCD NIH HHS R01DC000088NIDCD NIH HHS R01DC013817NIDCD NIH HHS R01 DC014712NIDCD NIH HHS R01DC014712NIDCD NIH HHS U01 DC013817
6 · The paper itself

Abstract

Recent studies have identified sex-differences in auditory physiology and in the susceptibility to noise-induced hearing loss (NIHL). We hypothesize that 17β-estradiol (E

Indexed as

CochleaHearing Loss, Noise-InducedAnimalsEstradiolEvoked Potentials, AuditoryFemaleMiceOvariectomyEstradiolauditory physiologycochlear synaptopathyestrogeninner earmouse modelnoise-induced hearing losssex-differences

Identifiers

PMID34830090
PMCPMC8620009
OpenAlexW3214429730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.