Evidence map›Paper›PMID 34830014›Full record

ArticleInternational journal of molecular sciences2021

Mild Muscle Mitochondrial Fusion Distress Extends

Andrea Tapia, Martina Palomino-Schätzlein, Marta Roca, Agustín Lahoz, Antonio Pineda-Lucena, Víctor López Del Amo, Máximo Ibo Galindo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Form and function of actin impacts actin health and aging.bioRxiv : the preprint server for biology · 2025
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Andrea TapiaCentro de Investigación Príncipe Felipe, 46012 Valencia, Spain.
Martina Palomino-SchätzleinCentro de Investigación Príncipe Felipe, 46012 Valencia, Spain.ORCID 0000-0001-7303-0743
Marta RocaAnalytical Unit, Medical Research Institute-Hospital La Fe, Av. Fernando Abril Martorell 106, 46026 Valencia, Spain.ORCID 0000-0003-0708-6364
Agustín LahozAnalytical Unit, Medical Research Institute-Hospital La Fe, Av. Fernando Abril Martorell 106, 46026 Valencia, Spain.ORCID 0000-0001-7232-0626
Antonio Pineda-LucenaMolecular Therapeutics Program, Centro de Investigación Médica Aplicada, Universidad de Navarra, 31008 Pamplona Spain.ORCID 0000-0002-3532-8781
Víctor López Del AmoSection of Cell and Developmental Biology, University of California, San Diego, CA 92093, USA.ORCID 0000-0002-5567-3072
Máximo Ibo GalindoCentro de Investigación Príncipe Felipe, 46012 Valencia, Spain.ORCID 0000-0001-8448-9760
Centro de Investigacion Principe Felipe · ESCIBBIM-Nanomedicine · ESLeitat Technological Center · ESUniversidad de Navarra · ESUniversity of California San Diego · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
European Commission OP ERDF of Comunitat Valenciana 2014-2020Generalitat Valenciana PROMETEU/2018/135NIH HHS P40 OD018537
6 · The paper itself

Abstract

In a global aging population, it is important to understand the factors affecting systemic aging and lifespan. Mitohormesis, an adaptive response caused by different insults affecting the mitochondrial network, triggers a response from the nuclear genome inducing several pathways that promote longevity and metabolic health. Understanding the role of mitochondrial function during the aging process could help biomarker identification and the development of novel strategies for healthy aging. Herein, we interfered the muscle expression of the

Indexed as

AgingAnimalsAnimals, Genetically ModifiedDrosophila melanogasterDrosophila ProteinsGene Expression Regulation, DevelopmentalLongevityMetabolomeMitochondrial DynamicsMitochondria, MuscleDrosophila ProteinsDrosophilainsulin pathwaylifespanmetabolomicsmitohormesis

Identifiers

PMID34830014
PMCPMC8618903
OpenAlexW3214311135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.