Evidence map›Paper›PMID 34830000›Full record

ReviewInternational journal of molecular sciences2021

The Importance of 6-Aminohexanoic Acid as a Hydrophobic, Flexible Structural Element.

Agnieszka Markowska, Adam Roman Markowski, Iwona Jarocka-Karpowicz

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

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  14. Mono-amino acid linkers enable highly potent small molecule-drug conjugates by conditional release.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  15. Article
  16. Evaluating theACS omega · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Agnieszka MarkowskaDepartment of Analytical Chemistry, Medical University of Bialystok, 15-089 Bialystok, Poland.ORCID 0000-0001-8685-5699
Adam Roman MarkowskiDepartment of Internal Medicine and Gastroenterology, Polish Red Cross Memorial Municipal Hospital, 79 Henryk Sienkiewicz Street, 15-003 Bialystok, Poland.ORCID 0000-0003-2115-5549
Iwona Jarocka-KarpowiczDepartment of Analytical Chemistry, Medical University of Bialystok, 15-089 Bialystok, Poland.ORCID 0000-0001-8923-3529
Medical University of Białystok · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

6-aminohexanoic acid is an ω-amino acid with a hydrophobic, flexible structure. Although the ω-amino acid in question is mainly used clinically as an antifibrinolytic drug, other applications are also interesting and important. This synthetic lysine derivative, without an α-amino group, plays a significant role in chemical synthesis of modified peptides and in the polyamide synthetic fibers (nylon) industry. It is also often used as a linker in various biologically active structures. This review concentrates on the role of 6-aminohexanoic acid in the structure of various molecules.

Indexed as

Amino AcidsAmino Acid SequenceAminocaproic AcidAntifibrinolytic AgentsBinding SitesHumansHydrophobic and Hydrophilic InteractionsLysinePeptidesAmino AcidsAminocaproic AcidAntifibrinolytic AgentsLysinePeptides6-aminohexanoic acidantifibrynolyticslinker

Identifiers

PMID34830000
PMCPMC8618066
OpenAlexW3211448670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.