Evidence map›Paper›PMID 34829999›Full record

ArticleInternational journal of molecular sciences2021

MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells.

Paulina Pietras, Marta Leśniczak-Staszak, Aldona Kasprzak, Małgorzata Andrzejewska, Karol Jopek, Mateusz Sowiński, Marcin Rucinski, Shawn M Lyons, Pavel Ivanov, Witold Szaflarski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Human Vault RNAs: Exploring Their Potential Role in Cellular Metabolism.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Paulina PietrasDepartment of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.
Marta Leśniczak-StaszakDepartment of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.
Aldona KasprzakDepartment of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.ORCID 0000-0002-1773-3038
Małgorzata AndrzejewskaDepartment of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.
Karol JopekDepartment of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.
Mateusz SowińskiDepartment of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.ORCID 0000-0003-3258-9609
Marcin RucinskiDepartment of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.ORCID 0000-0002-2525-5777
Shawn M LyonsDepartment of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.ORCID 0000-0002-2289-6392
Pavel IvanovDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
Witold SzaflarskiDepartment of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznań, Poland.
Poznan University of Medical Sciences · PLBoston University · USBroad Institute · US

Funding

Regulation of Ribosome Biogenesis During StressR00GM124458 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LYONS, SHAWN M · 2020 to 2022
$734k
National Science Centre in Poland UMO-2018/30/E/NZ7/00614NIGMS NIH HHS R00 GM124458
6 · The paper itself

Abstract

Cancer cells show significant dysregulation of genes expression, which may favor their survival in the tumor environment. In this study, the cellular vault's components MVP (major vault protein), TEP1 (telomerase-associated protein 1) and vPARP (vault poly(ADP-ribose) polymerase) were transiently or completely inhibited in U2OS cells (human bone osteosarcoma epithelial cells) to evaluate their impact on the cell proliferative and migratory capacity as well as on the development of their resistance to the drug vinorelbine. Comparative analysis of MVP protein expression level in normal colon tissue, primary colorectal tumor, and metastasis showed that the expression of this protein does not increase significantly in the primary tumor, but its expression increases in metastatic cells. Further comparative molecular analysis using the whole transcriptome microarrays for MVP-positive and MVP-negative cells showed that MVP is involved in regulating proliferation and migration of cancer cells. MVP may facilitate metastasis of colon cancer due to its impact on cell migration. Moreover, two vault proteins, MVP and TEP1, contribute the resistance to vinorelbine, while vPARP does not.

Indexed as

AdultAgedCell MovementCell ProliferationColorectal NeoplasmsDisease-Free SurvivalDrug Resistance, NeoplasmFemaleGene Expression Regulation, NeoplasticHumansMajor Vault ProteinMaleMiddle AgedNeoplasm MetastasisPoly(ADP-ribose) PolymerasesRNA-Binding ProteinsMajor Vault ProteinPoly(ADP-ribose) PolymerasesRNA-Binding ProteinsTEP1 protein, humanvault poly(ADP-ribose) polymeraseVault Ribonucleoprotein Particlescolorectal cancermetastasisMVPTEP1vaultsvPARP

Identifiers

PMID34829999
PMCPMC8623820
OpenAlexW3212426698

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.