Evidence map›Paper›PMID 34829997›Full record

ReviewInternational journal of molecular sciences2021

Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling.

Eva M Calderón-Sánchez, Débora Falcón, Marta Martín-Bórnez, Antonio Ordoñez, Tarik Smani

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Role of Peptides in Skeletal Muscle Wasting: A Scoping Review.Journal of cachexia, sarcopenia and muscle · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eva M Calderón-SánchezGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocío/University of Seville/CSIC, 41013 Seville, Spain.ORCID 0000-0002-9599-3513
Débora FalcónGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocío/University of Seville/CSIC, 41013 Seville, Spain.
Marta Martín-BórnezGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocío/University of Seville/CSIC, 41013 Seville, Spain.ORCID 0000-0002-9472-2666
Antonio OrdoñezGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocío/University of Seville/CSIC, 41013 Seville, Spain.ORCID 0000-0002-4344-8660
Tarik SmaniGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocío/University of Seville/CSIC, 41013 Seville, Spain.ORCID 0000-0002-1877-7438
Instituto de Biomedicina de Sevilla · ES

Funding

Instituto Carlos III PI18/01197Ministry of Economy, Industry and Competitiveness PID2019-104084GB-C22/AEI/10.13039/501100011033Regional Government of Andalusia PI-0193-2018
6 · The paper itself

Abstract

Despite the considerable progress in strategies of myocardial protection, ischemic heart diseases (IHD) and consequent heart failure (HF) remain the main cause of mortality worldwide. Several procedures are used routinely to guarantee the prompt and successful reestablishment of blood flow to preserve the myocardial viability of infarcted hearts from ischemia injuries. However, ischemic heart reperfusion/revascularization triggers additional damages that occur when oxygen-rich blood re-enters the vulnerable myocardial tissue, which is a phenomenon known as ischemia and reperfusion (I/R) syndrome. Complications of I/R injuries provoke the adverse cardiac remodeling, involving inflammation, mishandling of Ca

Indexed as

ApoptosisAtrial RemodelingHeartHeart FailureHumansMyocardial InfarctionMyocardial IschemiaMyocytes, CardiacOxygenReperfusion InjuryUrocortinsOxygenUrocortinsadverse cardiac remodelingcardioprotectionheart failureischemia and reperfusionurocortin

Identifiers

PMID34829997
PMCPMC8622004
OpenAlexW3214108398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.