Evidence map›Paper›PMID 34829912›Full record

ArticleBiomedicines2021

Wnt/β-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox

Ramona D'Amico, Marika Cordaro, Rosalba Siracusa, Daniela Impellizzeri, Angela Trovato Salinaro, Maria Scuto, Maria Laura Ontario, Roberto Crea, Salvatore Cuzzocrea, Rosanna Di Paola and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024
    Review
  7. Common miRNAs of Osteoporosis and Fibromyalgia: A Review.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Review
  10. Emotional arousal and valence in patients with fibromyalgia: a pilot study.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Article
  11. Antioxidants (Basel, Switzerland) · 2022
    Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ramona D'AmicoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.ORCID 0000-0003-0389-3871
Marika CordaroDepartment of Biomedical, Dental and Morphological and Functional Imaging, University of Messina, 98125 Messina, Italy.ORCID 0000-0002-3980-0043
Rosalba SiracusaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.ORCID 0000-0001-7868-2505
Daniela ImpellizzeriDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.ORCID 0000-0001-9492-3161
Angela Trovato SalinaroDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy.ORCID 0000-0003-2377-858X
Maria ScutoDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy.ORCID 0000-0003-1019-5158
Maria Laura OntarioDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy.
Roberto CreaOliphenol LLC., 26225 Eden Landing Road, Unit C, Hayward, CA 94545, USA.
Salvatore CuzzocreaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.ORCID 0000-0001-6131-3690
Rosanna Di PaolaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.ORCID 0000-0001-6725-8581
Roberta FuscoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.ORCID 0000-0003-0223-1403
Vittorio CalabreseDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy.ORCID 0000-0002-0478-985X
University of Messina · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibromyalgia (FM) is a chronic condition characterized by persistent widespread pain that negatively affects the quality of life of patients. The WNT/β-catenin signaling pathway seems to be involved in central sensitization and different pain states. The objective of this study was to investigate the beneficial effects of a new compound called Hidrox

Indexed as

fibromyalgiaNrf2 pathwaypainWNT/β-catenin pathway

Identifiers

PMID34829912
PMCPMC8615925
OpenAlexW3213582771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.