Evidence map›Paper›PMID 34829908›Full record

ArticleBiomedicines2021

Two-Step Approach Using Degradable Magnesium to Inhibit Surface Biofilm and Subsequently Kill Planktonic Bacteria.

Pei-Chun Wong, Ren-Yi Wang, Long-Sheng Lu, Wei-Ru Wang, Jason Shian-Ching Jang, Jia-Lin Wu, Tai-Yuan Su, Ling-Hua Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Pei-Chun WongDepartment of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0001-8357-5616
Ren-Yi WangGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Long-Sheng LuGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-4247-1981
Wei-Ru WangSchool of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Jason Shian-Ching JangDepartment of Mechanical Engineering, National Central University, Taoyuan 32001, Taiwan.ORCID 0000-0003-1507-3248
Jia-Lin WuDepartment of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Tai-Yuan SuDepartment Electrical Engineering, Yuan-Ze University, Chung-Li 32003, Taiwan.
Ling-Hua ChangDepartment Electrical Engineering, Yuan-Ze University, Chung-Li 32003, Taiwan.
Taipei Medical University Hospital · TWYuan Ze University · TWNational Central University · TWTaipei Medical University · TW

Funding

Ministry of Science and technology of Taiwan MOST 109-2221-E-155-035-MY3Ministry of Science and technology of Taiwan MOST 109-2314-B-038-149Ministry of Science and technology of Taiwan MOST 110-2221-E-155 -043 -MY3
6 · The paper itself

Abstract

Bacterial infection remains a great risk in medical implantation surgery. In this paper, we found that degradable metals may be a feasible alternative option of antibacterial implantation materials. It is known that the spalling mechanism of magnesium (Mg) during degradation leads to Mg ions-induced alkaline environment, which is harmful to planktonic bacteria. In this study, we showed that alkaline pH environment is almost harmless to those adhesive bacteria protected in well-formed biofilms. Moreover, experimental results demonstrated that the biofilm formed in the place where Mg spalls are destroyed, releasing the covered bacteria to be planktonic in the alkaline environment. As a result, the colonization of biofilms continues to shrink during the degradation of Mg. It implies that if degradable metal is employed as implantation material, even if bacterial infection occurs, it may be possibly cured without second surgery.

Indexed as

alkalineantibacterialbacterial infectionbiodegradationbiofilmmagnesiumspalling

Identifiers

PMID34829908
PMCPMC8615932
OpenAlexW3213235147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.