Evidence map›Paper›PMID 34829819›Full record

ReviewBiomedicines2021

Peripheral Nerve Stimulation for Treatment of Headaches: An Evidence-Based Review.

Steven Zhou, Nasir Hussain, Alaa Abd-Elsayed, Racha Boulos, Mohammed Hakim, Mayank Gupta, Tristan Weaver

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Innovations in Treating Headache.Life (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Interventional neuromodulation techniques for cervicogenic headache.Journal of anesthesia and translational medicine · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Steven ZhouDepartment of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Nasir HussainDepartment of Pain Medicine, Beth Israel Deaconess Medical Center, Harvard, Boston, MA 02215, USA.
Alaa Abd-ElsayedDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53715, USA.
Racha BoulosDepartment of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Mohammed HakimDepartment of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Mayank GuptaDepartment of Anesthesiology, Kansas City University of Medicine and Biosciences, Kansas City, MO 64106, USA.
Tristan WeaverDepartment of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
The Ohio State University Wexner Medical Center · USBeth Israel Deaconess Medical Center · USKansas City University · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Headaches are one of the most common medical complaints worldwide, and treatment is often made difficult because of misclassification. Peripheral nerve stimulation has emerged as a novel treatment for the treatment of intractable headaches in recent years. While high-quality evidence does exist regarding its use, efficacy is generally limited to specific nerves and headache types. While much research remains to bring this technology to the mainstream, clinicians are increasingly able to provide safe yet efficacious pain control.

Indexed as

headacheoccipital nerveperipheral nerve stimulationvagus nerve

Identifiers

PMID34829819
PMCPMC8615534
OpenAlexW3208821080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.