Evidence map›Paper›PMID 34829732›Full record

ArticleBiomedicines2021

Comparison of the Confluence-Initiated Neurogenic Differentiation Tendency of Adipose-Derived and Bone Marrow-Derived Mesenchymal Stem Cells.

Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. CELTCells · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Szu-Hsien WuDepartment of Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Yu-Ting LiaoDepartment of Orthopaedics & Traumatology, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Chi-Han HuangDepartment of Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Yi-Chou ChenDepartment of Orthopedics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan.
En-Rung ChiangDepartment of Surgery, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Jung-Pan WangDepartment of Surgery, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
National Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TWMinistry of Health and Welfare · TW

Funding

Ministry of Science and Technology Taiwan MOST 107-2314-B-075-031Taipei Veterans General Hospital V108C-102Taoyuan General Hospital, Ministry of Health and Welfare Taiwan PTH110023
6 · The paper itself

Abstract

Adipose-derived mesenchymal stem cells (ADSCs), which tended to neurogenically differentiate spontaneously after achieving high confluence, were observed. Human ADSCs reaching 80% confluence were cultured in DMEM without an inducing factor for 24 h and then maintained in DMEM plus 1% FBS medium for 7 days. The neurogenic, adipogenic, and osteogenic genes of the factor-induced and confluence-initiated differentiation of the ADSCs and bone marrow-derived mesenchymal stem cells (BMSCs) at passages 3 to 5 were determined and compared using RT-qPCR, and the neurogenic differentiation was confirmed using immunofluorescent staining. In vitro tests revealed that the RNA and protein expression of neuronal markers, including class III β-tubulin (

Indexed as

adipose-derived mesenchymal stem cells (ADSCs)bone marrow-derived mesenchymal stem cells (BMSCs)confluence-initiated differentiationneurogenic differentiation

Identifiers

PMID34829732
PMCPMC8615071
OpenAlexW3205415805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.