Evidence map›Paper›PMID 34829650›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Vitamin E Delivery Systems Increase Resistance to Oxidative Stress in Red Deer Sperm Cells: Hydrogel and Nanoemulsion Carriers.

Alejandro Jurado-Campos, Pedro Javier Soria-Meneses, Francisca Sánchez-Rubio, Enrique Niza, Iván Bravo, Carlos Alonso-Moreno, María Arenas-Moreira, Olga García-Álvarez, Ana Josefa Soler, José Julián Garde and 1 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. New Delivery Systems on Sperm Quality Improvement.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  5. Oxidative Status Measurement in Domestic and Wild Small Ruminants' Species.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Determination of Ram (Animals : an open access journal from MDPI · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Alejandro Jurado-CamposSaBio IREC (CSIC-UCLM-JCCM), Campus Universitario, s/n, 02071 Albacete, Spain.ORCID 0000-0002-5936-9561
Pedro Javier Soria-MenesesSaBio IREC (CSIC-UCLM-JCCM), Campus Universitario, s/n, 02071 Albacete, Spain.ORCID 0000-0001-5648-5308
Francisca Sánchez-RubioSaBio IREC (CSIC-UCLM-JCCM), Campus Universitario, s/n, 02071 Albacete, Spain.
Enrique NizaCentro Regional de Investigaciones Biomédicas, Unidad Nano-CRIB, 02071 Albacete, Spain.ORCID 0000-0003-2845-4509
Iván BravoCentro Regional de Investigaciones Biomédicas, Unidad Nano-CRIB, 02071 Albacete, Spain.ORCID 0000-0003-1589-5399
Carlos Alonso-MorenoCentro Regional de Investigaciones Biomédicas, Unidad Nano-CRIB, 02071 Albacete, Spain.ORCID 0000-0002-7588-0781
María Arenas-MoreiraSaBio IREC (CSIC-UCLM-JCCM), Campus Universitario, s/n, 02071 Albacete, Spain.ORCID 0000-0003-4112-669X
Olga García-ÁlvarezSaBio IREC (CSIC-UCLM-JCCM), Campus Universitario, s/n, 02071 Albacete, Spain.ORCID 0000-0003-4310-0557
Ana Josefa SolerSaBio IREC (CSIC-UCLM-JCCM), Campus Universitario, s/n, 02071 Albacete, Spain.ORCID 0000-0002-6429-5157
José Julián GardeSaBio IREC (CSIC-UCLM-JCCM), Campus Universitario, s/n, 02071 Albacete, Spain.ORCID 0000-0002-3667-6518
María Del Rocío Fernández-SantosSaBio IREC (CSIC-UCLM-JCCM), Campus Universitario, s/n, 02071 Albacete, Spain.
University of Castilla-La Mancha · ESComplejo Hospitalario Universitario de Albacete · ES

Funding

Ministerio de Ciencia e Innovación AGL2017-85603-P
6 · The paper itself

Abstract

Oxidative stress has become a major concern in the field of spermatology, and one of the possible solutions to this acute problem would be the use of antioxidant protection; however, more studies are required in this field, as highly contradictory results regarding the addition of antioxidants have been obtained. Vitamin E is a powerful biological antioxidant, but its low stability and high hydrophobicity limit its application in spermatology, making the use of organic solvents necessary, which renders spermatozoa practically motionless. Keeping this in mind, we propose the use of hydrogels (HVEs) and nanoemulsions (NVEs), alone or in combination, as carriers for the controlled release of vitamin E, thus, improving its solubility and stability and preventing oxidative stress in sperm cells. Cryopreserved sperm from six stags was thawed and extended to 30 × 10

Indexed as

antioxidanthydrogelnanoemulsionssperm oxidative stressvitamin E

Identifiers

PMID34829650
PMCPMC8615287
OpenAlexW3214529061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.