Evidence map›Paper›PMID 34829643›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Antioxidant Properties and Cytoprotective Effect of

Imen Ghzaiel, Amira Zarrouk, Thomas Nury, Michela Libergoli, Francesca Florio, Souha Hammouda, Franck Ménétrier, Laure Avoscan, Aline Yammine, Mohammad Samadi and 8 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Multifunctional Valorisation of Pistachio (International journal of molecular sciences · 2026
    Review
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  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Protective Effect of Nopal Cactus (International journal of molecular sciences · 2022
    Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 4 countries.

Imen GhzaielTeam 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA7270/Inserm, University Bourgogne Franche-Comté, 21000 Dijon, France.ORCID 0000-0001-8181-9445
Amira ZarroukLab-NAFS 'Nutrition-Functional Food & Vascular Health', Faculty of Medicine, University of Monastir, LR12ES05, Monastir 5000, Tunisia.ORCID 0000-0002-9190-5328
Thomas NuryTeam 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA7270/Inserm, University Bourgogne Franche-Comté, 21000 Dijon, France.ORCID 0000-0002-2190-9630
Michela LibergoliDepartment of Cellular, Computational and Integrative Biology (CIBio) and Dulbecco Telethon Institute, University of Trento, 38123 Trento, Italy.
Francesca FlorioDepartment of Cellular, Computational and Integrative Biology (CIBio) and Dulbecco Telethon Institute, University of Trento, 38123 Trento, Italy.
Souha HammoudaLab-NAFS 'Nutrition-Functional Food & Vascular Health', Faculty of Medicine, University of Monastir, LR12ES05, Monastir 5000, Tunisia.ORCID 0000-0001-5987-1909
Franck MénétrierCentre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, 21065 Dijon, France.
Laure AvoscanAgroécologie, AgroSup Dijon, CNRS, INRAE, University Bourgogne Franche-Comté, Plateforme DimaCell, 21000 Dijon, France.
Aline YammineTeam 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA7270/Inserm, University Bourgogne Franche-Comté, 21000 Dijon, France.
Mohammad SamadiLCPMC-A2, ICPM, Department of Chemistry, University Lorraine, Metz Technopôle, 57070 Metz, France.
Norbert LatruffeTeam 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA7270/Inserm, University Bourgogne Franche-Comté, 21000 Dijon, France.ORCID 0000-0001-6794-2690
Stefano BiressiDepartment of Cellular, Computational and Integrative Biology (CIBio) and Dulbecco Telethon Institute, University of Trento, 38123 Trento, Italy.ORCID 0000-0001-8631-3419
Débora LevyLipids, Oxidation and Cell Biology Team, Laboratory of Immunology (LIM19), Heart Institute (InCor), Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-900, Brazil.ORCID 0000-0001-7492-997X
Sérgio Paulo BydlowskiLipids, Oxidation and Cell Biology Team, Laboratory of Immunology (LIM19), Heart Institute (InCor), Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-900, Brazil.ORCID 0000-0002-7582-5942
Sonia HammamiLab-NAFS 'Nutrition-Functional Food & Vascular Health', Faculty of Medicine, University of Monastir, LR12ES05, Monastir 5000, Tunisia.
Anne VejuxTeam 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA7270/Inserm, University Bourgogne Franche-Comté, 21000 Dijon, France.ORCID 0000-0002-4063-9680
Mohamed HammamiLab-NAFS 'Nutrition-Functional Food & Vascular Health', Faculty of Medicine, University of Monastir, LR12ES05, Monastir 5000, Tunisia.
Gérard LizardTeam 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA7270/Inserm, University Bourgogne Franche-Comté, 21000 Dijon, France.ORCID 0000-0001-6330-0172
Inserm · FRUniversity of Monastir · TNUniversity of Trento · ITCentre National de la Recherche Scientifique · FRUniversidade de São Paulo · BRTunis University · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is characterized by a progressive increase in oxidative stress, which favors lipid peroxidation and the formation of cholesterol oxide derivatives, including 7β-hydroxycholesterol (7β-OHC). This oxysterol, which is known to trigger oxidative stress, inflammation, and cell death, could contribute to the aging process and age-related diseases, such as sarcopenia. Identifying molecules or mixtures of molecules preventing the toxicity of 7β-OHC is therefore an important issue. This study consists of determining the chemical composition of Tunisian

Indexed as

7β-hydroxycholesterolagingC2C12 myoblastsmitochondriaoxidative stressperoxisomePistacia lentiscus L. seed oilsarcopenia

Identifiers

PMID34829643
PMCPMC8615043
OpenAlexW3214534905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.