Evidence map›Paper›PMID 34829578›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Phenolic Thiazoles with Antioxidant and Antiradical Activity. Synthesis, In Vitro Evaluation, Toxicity, Electrochemical Behavior, Quantum Studies and Antimicrobial Screening.

Gabriel Marc, Anca Stana, Ana Horiana Franchini, Dan Cristian Vodnar, Gabriel Barta, Mihaela Tertiş, Iulia Şanta, Cecilia Cristea, Adrian Pîrnău, Alexandra Ciorîţă and 5 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  11. CoumarinAntioxidants (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Gabriel MarcDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania.ORCID 0000-0001-9397-0388
Anca StanaDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania.ORCID 0000-0002-8453-3642
Ana Horiana FranchiniDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania.
Dan Cristian VodnarDepartment of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 3-5 Manăştur Street, RO-400372 Cluj-Napoca, Romania.ORCID 0000-0001-5407-8071
Gabriel BartaDepartment of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 3-5 Manăştur Street, RO-400372 Cluj-Napoca, Romania.ORCID 0000-0001-5501-2744
Mihaela TertişDepartment of Analytical Chemistry, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 4 Louis Pasteur Street, RO-400349 Cluj-Napoca, Romania.ORCID 0000-0003-2572-6724
Iulia ŞantaDepartment of Analytical Chemistry, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 4 Louis Pasteur Street, RO-400349 Cluj-Napoca, Romania.
Cecilia CristeaDepartment of Analytical Chemistry, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 4 Louis Pasteur Street, RO-400349 Cluj-Napoca, Romania.ORCID 0000-0002-4158-3324
Adrian PîrnăuNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath Street, RO-400293 Cluj-Napoca, Romania.ORCID 0000-0002-2313-9350
Alexandra CiorîţăNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath Street, RO-400293 Cluj-Napoca, Romania.ORCID 0000-0003-2991-3957
Bogdan DumeDepartment of Molecular Biology and Biotechnologies, Babeș-Bolyai University, 4-6 Clinicilor Street, RO-400006 Cluj-Napoca, Romania.
Vlad-Alexandru TomaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath Street, RO-400293 Cluj-Napoca, Romania.
Laurian VlaseDepartment of Pharmaceutical Technology and Biopharmaceutics, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania.ORCID 0000-0002-0664-3387
Ilioara OnigaDepartment of Pharmacognosy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 Ion Creangă Street, RO-400010 Cluj-Napoca, Romania.ORCID 0000-0002-7660-9993
Ovidiu OnigaDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania.
Iuliu Hațieganu University of Medicine and Pharmacy · ROBabeș-Bolyai University · ROUniversity of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca · RONational Institute for Research and Development of Isotopic and Molecular Technologies · RO

Funding

European Social Found, Human Capital Operational Programme 2014-2020 POCU/380/6/13/125171"IULIU HAŢIEGANU" UNIVERSITY OF MEDICINE AND PHARMACY, Cluj-Napoca, Romania PCD 7690/68/15.04.2016ROMANIAN MINISTRY OF RESEARCH AND INNOVATION PN 19 35 02 01
6 · The paper itself

Abstract

Oxidative stress represents the underlying cause of many chronic diseases in human; therefore, the development of potent antioxidant compounds for preventing or treating such conditions is useful. Starting from the good antioxidant and antiradical properties identified for the previously reported Dihydroxy-Phenyl-Thiazol-Hydrazinium chloride (DPTH), we synthesized a congeneric series of phenolic thiazoles. The radical scavenging activity, and the antioxidant and chelation potential were assessed in vitro, a series of quantum descriptors were calculated, and the electrochemical behavior of the synthesized compounds was studied to evaluate the impact on the antioxidant and antiradical activities. In addition, their antibacterial and antifungal properties were evaluated against seven aerobic bacterial strains and a strain of

Indexed as

antimicrobial activityantioxidant activityantiradical activitycytotoxicityelectrochemical behaviorpolyphenolsquantum studiessynthesisthiazole

Identifiers

PMID34829578
PMCPMC8615111
OpenAlexW3209479439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.