ReviewAntioxidants (Basel, Switzerland)2021
Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress.
Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Acute radiation-induced changes in the submandibular salivary gland and possible radioprotective role of silver nanoparticles: a histological, immunohistochemical, and ultrastructural study.Anatomy & cell biology · 2026Article
- Photobiomodulation for salivary gland dysfunction: aligning clinical expectations with etiology-dependent treatment responsiveness.Lasers in medical science · 2026Review
- Differential metabolic responses to hydrogen peroxide-induced oxidative stress in parotid and submandibular gland acinar cell lines.Biochemistry and biophysics reports · 2026Article
- Targeting Ferroptosis to Restore Salivary Gland Homeostasis in an Obesity Model.International journal of molecular sciences · 2026Article
- Evaluating microbial regulation as a preventive strategy for radiation-related caries: A review.Head & face medicine · 2025Review
- Regenerative potential of the intermediate filaments of albino rat parotid glands subjected to fractionated radiotherapy: an immunohistochemical analysis.Acta odontologica Scandinavica · 2025Article
- Poly (hydroxyethyl methacrylate) Saliva-Gel: A Polymer-Based Solution for Xerostomia Treatment.ACS applied polymer materials · 2025Article
- Evaluation of Regeneration Potential of Bone Marrow-Derived Mesenchymal Stem Cells on Induced Damaged Submandibular Salivary Gland in Mice.European journal of dentistry · 2025Article
- Article
- Current basic and preclinical research for treatment of radiation therapy-induced hyposalivation.JADA foundational science · 2025Article
- Article
- Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress.Antioxidants (Basel, Switzerland) · 2024Article
- A new approach to prevent radiation-induced xerostomia using intraglandular injection of mitochondria-boosting agents.BMC cancer · 2024Article
- Iron overload induced submandibular glands toxicity in gamma irradiated rats with possible mitigation by hesperidin and rutin.BMC pharmacology & toxicology · 2024Article
- Tetrahedral framework nucleic acids alleviate irradiation-induced salivary gland damage.Cell proliferation · 2023Article
- Salidroside Ameliorates Radiation Damage by Reducing Mitochondrial Oxidative Stress in the Submandibular Gland.Antioxidants (Basel, Switzerland) · 2022Article
- Mesenchymal stem cells in radiation-induced lung injury: From mechanisms to therapeutic potential.Frontiers in cell and developmental biology · 2022Review
- Cooperation effects of radiation and ferroptosis on tumor suppression and radiation injury.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Radiation therapy is a common treatment for head and neck cancers. However, because of the presence of nerve structures (brain stem, spinal cord, and brachial plexus), salivary glands (SGs), mucous membranes, and swallowing muscles in the head and neck regions, radiotherapy inevitably causes damage to these normal tissues. Among them, SG injury is a serious adverse event, and its clinical manifestations include changes in taste, difficulty chewing and swallowing, oral infections, and dental caries. These clinical symptoms seriously reduce a patient's quality of life. Therefore, it is important to clarify the mechanism of SG injury caused by radiotherapy. Although the mechanism of radiation-induced SG injury has not yet been determined, recent studies have shown that the mechanisms of calcium signaling, microvascular injury, cellular senescence, and apoptosis are closely related to oxidative stress. In this article, we review the mechanism by which radiotherapy causes oxidative stress and damages the SGs. In addition, we discuss effective methods to prevent and treat radiation-induced SG damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.