Evidence map›Paper›PMID 34829454›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Abnormal Circulating Maternal miRNA Expression Is Associated with a Low (<4%) Cell-Free DNA Fetal Fraction.

Graziano Santoro, Cristina Lapucci, Marco Giannoccaro, Simona Caporilli, Martina Rusin, Anna Seidenari, Maurizio Ferrari, Antonio Farina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Graziano SantoroGenetic Unit, Synlab, Via B. L. Pavoni 18, Castenedolo, 25014 Brescia, Italy.ORCID 0000-0002-6459-5846
Cristina LapucciGenetic Unit, Synlab, Via B. L. Pavoni 18, Castenedolo, 25014 Brescia, Italy.
Marco GiannoccaroGenetic Unit, Synlab, Via B. L. Pavoni 18, Castenedolo, 25014 Brescia, Italy.
Simona CaporilliGenetic Unit, Synlab, Via B. L. Pavoni 18, Castenedolo, 25014 Brescia, Italy.
Martina RusinDivision of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC), IRCCS Sant'Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-3012-2653
Anna SeidenariDivision of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC), IRCCS Sant'Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy.
Maurizio FerrariIRCCS, SDN, Via Gianturco 113, 80143 Naples, Italy.
Antonio FarinaDivision of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC), IRCCS Sant'Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-6862-1810
IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITSDN Istituto di Ricerca Diagnostica e Nucleare · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present pilot study investigates whether an abnormal miRNA profile in NIPT plasma samples can explain the finding of a low cell-free DNA (cfDNA) fetal fraction (cfDNAff) in euploid fetuses and non-obese women. Twelve women who underwent neoBona

Indexed as

low cell-free DNA (cfDNA) fetal fractionmiRNANIPT

Identifiers

PMID34829454
PMCPMC8625387
OpenAlexW3212645832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.