Evidence map›Paper›PMID 34829450›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Improved Alzheimer's Disease Detection by MRI Using Multimodal Machine Learning Algorithms.

Gopi Battineni, Mohmmad Amran Hossain, Nalini Chintalapudi, Enea Traini, Venkata Rao Dhulipalla, Mariappan Ramasamy, Francesco Amenta

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  7. Plasma p-tau217 and p-tau217/AβScientific reports · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gopi BattineniTelemedicine and Telepharmacy Centre, School of Medicinal and Health Products Sciences, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0003-0603-2356
Mohmmad Amran HossainTelemedicine and Telepharmacy Centre, School of Medicinal and Health Products Sciences, University of Camerino, 62032 Camerino, Italy.
Nalini ChintalapudiTelemedicine and Telepharmacy Centre, School of Medicinal and Health Products Sciences, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0003-0818-306X
Enea TrainiTelemedicine and Telepharmacy Centre, School of Medicinal and Health Products Sciences, University of Camerino, 62032 Camerino, Italy.
Venkata Rao DhulipallaThe Research Centre of the ECE Department, V.R. Siddhartha Engineering College, Vijayawada 521002, Andhra Pradesh, India.
Mariappan RamasamyThe Research Centre of the ECE Department, V.R. Siddhartha Engineering College, Vijayawada 521002, Andhra Pradesh, India.
Francesco AmentaTelemedicine and Telepharmacy Centre, School of Medicinal and Health Products Sciences, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0002-0555-1034

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult-onset dementia disorders represent a challenge for modern medicine. Alzheimer's disease (AD) represents the most diffused form of adult-onset dementias. For half a century, the diagnosis of AD was based on clinical and exclusion criteria, with an accuracy of 85%, which did not allow for a definitive diagnosis, which could only be confirmed by post-mortem evaluation. Machine learning research applied to Magnetic Resonance Imaging (MRI) techniques can contribute to a faster diagnosis of AD and may contribute to predicting the evolution of the disease. It was also possible to predict individual dementia of older adults with AD screening data and ML classifiers. To predict the AD subject status, the MRI demographic information and pre-existing conditions of the patient can help to enhance the classifier performance. In this work, we proposed a framework based on supervised learning classifiers in the dementia subject categorization as either AD or non-AD based on longitudinal brain MRI features. Six different supervised classifiers are incorporated for the classification of AD subjects and results mentioned that the gradient boosting algorithm outperforms other models with 97.58% of accuracy.

Indexed as

Alzheimer’s diseaseAUROCDementiamachine learningperformanceprediction

Identifiers

PMID34829450
PMCPMC8623867

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.