Evidence map›Paper›PMID 34829437›Full record

ReviewDiagnostics (Basel, Switzerland)2021

The Pathology of Type 2 Inflammation-Associated Itch in Atopic Dermatitis.

Catharina Sagita Moniaga, Mitsutoshi Tominaga, Kenji Takamori

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. The Philosophy of Dermatopathology.Diagnostics (Basel, Switzerland) · 2022
    Article
  12. Review
  13. Article
  14. Update on the pathogenesis of atopic dermatitis.Anais brasileiros de dermatologia
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Catharina Sagita MoniagaJuntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Graduate School of Medicine, Juntendo University, 2-1-1 Tomioka, Urayasu 279-0021, Japan.
Mitsutoshi TominagaJuntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Graduate School of Medicine, Juntendo University, 2-1-1 Tomioka, Urayasu 279-0021, Japan.ORCID 0000-0002-1254-1803
Kenji TakamoriJuntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Graduate School of Medicine, Juntendo University, 2-1-1 Tomioka, Urayasu 279-0021, Japan.ORCID 0000-0002-0644-0504

Funding

Foundation of Strategic Research Projects in Private Universities from the Ministry of Education, Culture, Sports, Science, and Technology, Japan S1311011Ministry of Health, Labour, and Welfare, 18K07396, 20H03568
6 · The paper itself

Abstract

Accumulated evidence on type 2 inflammation-associated itch in atopic dermatitis has recently been reported. Crosstalk between the immune and nervous systems (neuroimmune interactions) is prominent in atopic dermatitis research, particularly regarding itch and inflammation. A comprehensive understanding of bidirectional neuroimmune interactions will provide insights into the pathogenesis of itch and its treatment. There is currently no agreed cure for itch in atopic dermatitis; however, increasing numbers of novel and targeted biologic agents have potential for its management and are in the advanced stages of clinical trials. In this review, we summarize and discuss advances in our understanding of type 2 inflammation-associated itch and implications for its management and treatment in patients with atopic dermatitis.

Indexed as

atopic dermatitisbiologic agentsneuroimmune interactionstype 2 inflammation

Identifiers

PMID34829437
PMCPMC8618746

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.