ArticleDiagnostics (Basel, Switzerland)2021
Immunological Trajectories of White Blood Cells from Adolescence to Adulthood: Description and Determinants.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- How the metabolic phenotype in adulthood is affected by long-lasting immunological trajectories since adolescence.Scientific reports · 2022Article
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5 authors.
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Abstract
backgroundThe immune system gradually matures early in life in the face of internal and external stimuli. Whether the immune responses are lasting and stable during the course of life is still unclear.
methodsAs part of the EPITeen cohort, 1183 adolescents were prospectively evaluated at the ages of 13, 17, 21, 24 and 27. Sociodemographic, behavioral and clinical data were collected by self- and face-to-face-administered questionnaires, along with a physical examination comprising anthropometric measurements and blood sample collections. Mixed-effects models were used to identify individual trajectories of white blood cells (WBC) and finite Gaussian mixture models were used to identify the clusters of individual trajectories.
resultsParticipants were allocated into six clusters based on the individual trajectories of WBC distribution.
conclusionsIn this study we identified distinct immunological trajectories of WBC from adolescence to adulthood that were associated with social, clinical and behavioral determinants. These results suggest that these immunological trajectories are defined early in life, being dependent on the exposures.
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